Sarcopenia
Conditions
Keywords
Krill oil, Muscle strength, Muscle mass, Middle-aged
Brief summary
This study will determine the effect of 6 months of supplementation with krill oil on muscle strength and mass in middle-aged adults. The study hypothesis is that krill oil supplementation will increase muscle strength and mass in middle-aged adults.
Interventions
DIETARY_SUPPLEMENTKrill oil
Superba krill oil
DIETARY_SUPPLEMENTVegetable oil
Mixed vegetable oil
Sponsors
University of Glasgow
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Masking description
Supplements will be identical in look and taste
Intervention model description
1:1 basis
Eligibility
Sex/Gender
ALL
Age
35 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Be 35-60 years old * Have a BMI of less than 35kg/m2
Exclusion criteria
* People with diabetes, severe cardiovascular disease, seizure disorders, uncontrolled hypertension (\>150/90mmHg at baseline measurement), cancer or cancer that has been in remission \<5 years, ambulatory impairments which would limit the ability to perform assessments of muscle function, dementia, on anticoagulant therapy, and/or taking medication known to affect muscle (e.g., steroids). * People who have allergies to seafood, and/or regular consumption of more than 1 portion of oily fish per week. * People who perform regular (\>1 day/week) resistance exercise training.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in knee extensor maximal isometric torque ( MVC) | Change from baseline to 24 weeks | Knee extensor maximal isometric torque measured during a maximal voluntary contraction |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in lean mass | Change from baseline to 24 weeks | Whole body lean mass measured by measured via bio-electrical impedance |
| Change in omega-3 levels | Change from baseline to 24 weeks | Red blood cell omega-3 levels |
| Change in Grip strength | Change from baseline to 24 weeks | Grip strength measured with a hand held dynamometer |
| Change in Muscle thickness | Change from baseline to 24 weeks | Vastus lateralis muscle thickness measured by ultrasound |
| Change in fat mass | Change from baseline to 24 weeks | Whole body fat mass measured by measured via bio-electrical impedance |
Other
| Measure | Time frame | Description |
|---|---|---|
| Change in muscle anabolic signalling | Change from baseline to 24 weeks | Muscle total and phosphorylated protein levels of mTOR, IRS-1, Akt, 4EBP-1, p70S6K, RPS6, FOXO-1, GSK3β and total protein levels of MAFBx and MURF-1 |
| Change in muscle inflammation | Change from baseline to 24 weeks | Muscle total protein levels of TNF-α, IL-1β, IL-6, IL-8, MCP-1 and total and phosphorylated levels of NFκB, JNK1/2 and STAT3 |
| Change in systemic inflammation | Change from baseline to 24 weeks | Plasma levels of C-reactive protein, IL-1, IL-6, IL-8, IL-10, and TNF-α |
Countries
United Kingdom
Outcome results
None listed