Effect of Acetaminophen Preemptive Analgesia on Postoperative Cognitive Function

Effects of Acetaminophen Preemptive Analgesia on Anesthesia Recovery Time and Postoperative Cognitive Function in Patients Undergoing Gastrointestinal Tumor Surgery

Status

UNKNOWN

Phases

Phase 1Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06004687

Enrollment

100

Registered

2023-08-22

Start date

2023-07-26

Completion date

2024-12-30

Last updated

2023-08-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognitive Function

Keywords

acetaminophen mannitol, cognitive function, anesthesia recovery time, gastrointestinal tumor surgery

Brief summary

Patients undergoing gastrointestinal tumor surgery are prone to delayed recovery and postoperative cognitive dysfunction due to greater trauma and longer operation time. Pre-analgesia can reverse the effects of nociceptive stimulation on recovery from general anesthesia and postoperative cognitive function. Intravenous injection of non-steroidal drugs can effectively reduce postoperative pain and the use of opioids. Therefore, This study selected acetaminophen mannitol injection for preemptive analgesia to observe the effects on anesthesia recovery time and postoperative cognitive function of patients undergoing gastrointestinal tumor surgery, providing new ideas for reducing cognitive dysfunction in patients undergoing gastrointestinal tumor surgery

Detailed description

By administering acetaminophen to patients with gastrointestinal tumors before surgery, recording the time to recovery from anesthesia, and assessing cognitive function status by CAM on the first, third, and seventh day after surgery

Interventions

DRUGacetaminophen mannitol

Intravenous acetaminophen was administered 30 minutes before anesthesia

DRUGNormal saline

Intravenous acetaminophen was administered 30 minutes before anesthesia

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

ALL

Age

16 Years to 88 Years

Healthy volunteers

Inclusion criteria

* Patients undergoing gastrointestinal tumor surgery * American Society of Anesthesiologists（ASA）≤Ⅲ

Exclusion criteria

* History of severe adverse reactions to oral acetaminophen * Dysfunction of heart, liver, kidney and other important organs * History of chronic pain * Oral non-steroidal or opioid drugs * Patients who do not accept clinical trials

Design outcomes

Primary

Measure	Time frame	Description
Postoperative delirium	1/3/7 days after the surgery	The confusion assessment method (CAM) was used to assess postoperative cognitive dysfunction

Secondary

Measure	Time frame	Description
Recovery time	immediately after the surgery	The postoperative recovery time was recorded

Other

Measure	Time frame	Description
Neurotransmitters in the blood	1/3/7 days after the surgery	Neurotransmitters include epinephrine, norepinephrine, and so on

Countries

China

Contacts

Primary ContactHongsheng Chen

chenhongsheng8@163.com+86 513 81160313

Backup ContactChaochao Zhong

+86 513 81160313

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026