Healthy
Conditions
Brief summary
The purpose of this study is to learn about the tastes of different suspensions with the study medicine called PF-07923568 in healthy adult participants. In a suspension, the medicine is mixed with a liquid, usually water, in which it cannot dissolve and therefore remains intact in the form of small particles. This study is seeking for healthy participants who: * are aged 18 years of age or older. * can produce a baby must agree to use a highly effective method of birth control. * are confirmed to be healthy by some medical tests. This study can include both men and women. * have body mass index (BMI) of 16 to 32 kg/m2 and a total body weight of more than 45 kilograms. Participants will take sisunatovir prepared in 5 different suspensions and bitrex over two days to see if they are good to taste. Participants will answer a questionnaire after tasting each suspension. The questionnaire will be completed for each suspension. The questionnaire asks participants to test each suspension at 4 different times after tasting and spitting out the suspension. At least 60 minutes will pass between tasting each suspension. The total planned time period of participation is around 5 to 8 weeks. This includes the screening period of up to 28 days. Followed by first administration of study medicine. Then a 3 day in-patient stay at the study clinic. It also includes a follow-up phone call that happens 28-35 days after the final taste test.
Interventions
DRUGSinsunatovir
Single dose, to be spit out after tasting
OTHERBitrex
Single dose, to be spit out after tasting
Sponsors
Pfizer
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Male and female participants aged 18 years or older (or the minimum age of consent in accordance with local regulations) at screening who are overtly healthy as determined by medical evaluation including medical history, physical examination, laboratory tests, blood pressure, pulse rate and standard 12-lead electrocardiogram (ECG). * Body mass index (BMI) of 16-32 kg/m2; and a total body weight \>45 kg
Exclusion criteria
* Evidence or history of clinically significant hematological, renal, endocrine,pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurological, or allergic disease (including drug allergies, but excluding untreated, asymptomatic, seasonal allergies at the time of dosing). * Any medical or psychiatric condition including recent (within the past year) or active suicidal ideation/behavior or laboratory abnormality or other conditions that may increase the risk of study participation or, in the investigator's judgment, make the participant inappropriate for the study. * Conditions that affect ability to taste eg, dysgeusia, respiratory infection, cold, etc. * History of hypersensitivity to the active compounds or to any inactive ingredients (excipients) contained in the formulations. * Previous administration with an investigational product (drug or vaccine) within 30 days (or as determined by the local requirement) or 5 half-lives preceding the first dose of study intervention used in this study (whichever is longer). Participation in studies of other investigational products (drug or vaccine) at any time during their participation in this study. * A positive urine drug test at screening or admission. * A positive serum pregnancy test at screening and/or positive urine/serum pregnancy test in woman/women of childbearing potential (WOCBP) at Day -1 * Use of tobacco/nicotine containing products * Screening supine blood pressure (BP) ≥140 mm Hg (systolic) or ≥90 mm Hg (diastolic) for participants \<60 years; and ≥150/90 mm Hg for participants ≥60 years old, following at least 5 minutes of supine rest. * Renal impairment as defined by an estimated glomerular filtration rate (eGFR) (units of mL/min/1.73m²) \<60 mL/min(/1.73m²) based on 2021 chronic kidney disease epidemiology (CKD-EPI). * Standard 12-lead ECG that demonstrates clinically relevant abnormalities that may affect participant safety or interpretation of study results * Alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin (Bili) ≥ 1.05 × upper limit of normal (ULN). Participants with an elevated total bilirubin consistent with Gilbert's Disease should have a direct bilirubin measured and would be eligible for this study provided the direct bilirubin level is ≤ ULN.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 2 | At 20 minutes after tasting specified study formulation on Day 2 | Participants were offered formulation for tasting where they had to swirl sample in their mouth for approximately 10 seconds, and then spit it out. Participant had to assess each sensory attribute on scale of 0 (good) to 100 (bad) after tasting formulation, lower score= better palatability. Following were sensory attributes: mouth feel (grittiness/stickiness or waxiness, 0= normal mouth feel,100=bad mouth feel);bitterness (degree of bitterness of the product, 0= not bitter at all,100= extremely bitter); sweetness(degree of sweet taste,0=sweet, 100= not sweet at all); sourness (degree of sour taste,0= not sour at all,100= extremely sour);saltiness(degree of salty taste,0=not salty at all,100= extremely salty); tongue/mouth burn(degree of tongue/mouth burn,0= no burn at all,100= extreme burn);overall liking (how much like or dislike product, 0= like, 100= dislike).Mean score for each sensory attributes based on palatability assessment questionnaire are reported in this outcome measure. |
| Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 2 | At 1 minute after tasting specified study formulation on Day 2 | Participants were offered formulation for tasting where they had to swirl sample in their mouth for approximately 10 seconds, and then spit it out. Participant had to assess each sensory attribute on scale of 0 (good) to 100 (bad) after tasting formulation, lower score= better palatability. Following were sensory attributes: mouth feel (grittiness/stickiness or waxiness, 0= normal mouth feel,100=bad mouth feel);bitterness (degree of bitterness of the product, 0= not bitter at all,100= extremely bitter); sweetness(degree of sweet taste,0=sweet, 100= not sweet at all); sourness (degree of sour taste,0= not sour at all,100= extremely sour);saltiness(degree of salty taste,0=not salty at all,100= extremely salty); tongue/mouth burn(degree of tongue/mouth burn,0= no burn at all,100= extreme burn);overall liking (how much like or dislike product, 0= like, 100= dislike).Mean score for each sensory attributes based on palatability assessment questionnaire are reported in this outcome measure. |
| Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 2 | At 5 minutes after tasting specified study formulation on Day 2 | Participants were offered formulation for tasting where they had to swirl sample in their mouth for approximately 10 seconds, and then spit it out. Participant had to assess each sensory attribute on scale of 0 (good) to 100 (bad) after tasting formulation, lower score= better palatability. Following were sensory attributes: mouth feel (grittiness/stickiness or waxiness, 0= normal mouth feel,100=bad mouth feel);bitterness (degree of bitterness of the product, 0= not bitter at all,100= extremely bitter); sweetness(degree of sweet taste,0=sweet, 100= not sweet at all); sourness (degree of sour taste,0= not sour at all,100= extremely sour);saltiness(degree of salty taste,0=not salty at all,100= extremely salty); tongue/mouth burn(degree of tongue/mouth burn,0= no burn at all,100= extreme burn);overall liking (how much like or dislike product, 0= like, 100= dislike).Mean score for each sensory attributes based on palatability assessment questionnaire are reported in this outcome measure. |
| Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 2 | At 10 minutes after tasting specified study formulation on Day 2 | Participants were offered formulation for tasting where they had to swirl sample in their mouth for approximately 10 seconds, and then spit it out. Participant had to assess each sensory attribute on scale of 0 (good) to 100 (bad) after tasting formulation, lower score= better palatability. Following were sensory attributes: mouth feel (grittiness/stickiness or waxiness, 0= normal mouth feel,100=bad mouth feel);bitterness (degree of bitterness of the product, 0= not bitter at all,100= extremely bitter); sweetness(degree of sweet taste,0=sweet, 100= not sweet at all); sourness (degree of sour taste,0= not sour at all,100= extremely sour);saltiness(degree of salty taste,0=not salty at all,100= extremely salty); tongue/mouth burn(degree of tongue/mouth burn,0= no burn at all,100= extreme burn);overall liking (how much like or dislike product, 0= like, 100= dislike).Mean score for each sensory attributes based on palatability assessment questionnaire are reported in this outcome measure. |
| Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 1 | At 1 minute after tasting specified study formulation on Day 1 | Participants were offered formulation for tasting where they had to swirl sample in their mouth for approximately 10 seconds, and then spit it out. Participant had to assess each sensory attribute on scale of 0 (good) to 100 (bad) after tasting formulation, lower score= better palatability. Following were sensory attributes: mouth feel (grittiness/stickiness or waxiness, 0= normal mouth feel,100=bad mouth feel);bitterness (degree of bitterness of the product, 0= not bitter at all,100= extremely bitter); sweetness(degree of sweet taste,0=sweet, 100= not sweet at all); sourness (degree of sour taste,0= not sour at all,100= extremely sour);saltiness(degree of salty taste,0=not salty at all,100= extremely salty); tongue/mouth burn(degree of tongue/mouth burn,0= no burn at all,100= extreme burn);overall liking (how much like or dislike product, 0= like, 100= dislike).Mean score for each sensory attributes based on palatability assessment questionnaire are reported in this outcome measure. |
| Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 1 | At 5 minutes after tasting specified study formulation on Day 1 | Participants were offered formulation for tasting where they had to swirl sample in their mouth for approximately 10 seconds, and then spit it out. Participant had to assess each sensory attribute on scale of 0 (good) to 100 (bad) after tasting formulation, lower score= better palatability. Following were sensory attributes: mouth feel (grittiness/stickiness or waxiness, 0= normal mouth feel,100=bad mouth feel);bitterness (degree of bitterness of the product, 0= not bitter at all,100= extremely bitter); sweetness(degree of sweet taste,0=sweet, 100= not sweet at all); sourness (degree of sour taste,0= not sour at all,100= extremely sour);saltiness(degree of salty taste,0=not salty at all,100= extremely salty); tongue/mouth burn(degree of tongue/mouth burn,0= no burn at all,100= extreme burn);overall liking (how much like or dislike product, 0= like, 100= dislike).Mean score for each sensory attributes based on palatability assessment questionnaire are reported in this outcome measure. |
| Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 1 | At 10 minutes after tasting specified study formulation on Day 1 | Participants were offered formulation for tasting where they had to swirl sample in their mouth for approximately 10 seconds, and then spit it out. Participant had to assess each sensory attribute on scale of 0 (good) to 100 (bad) after tasting formulation, lower score= better palatability. Following were sensory attributes: mouth feel (grittiness/stickiness or waxiness, 0= normal mouth feel,100=bad mouth feel);bitterness (degree of bitterness of the product, 0= not bitter at all,100= extremely bitter); sweetness(degree of sweet taste,0=sweet, 100= not sweet at all); sourness (degree of sour taste,0= not sour at all,100= extremely sour);saltiness(degree of salty taste,0=not salty at all,100= extremely salty); tongue/mouth burn(degree of tongue/mouth burn,0= no burn at all,100= extreme burn);overall liking (how much like or dislike product, 0= like, 100= dislike).Mean score for each sensory attributes based on palatability assessment questionnaire are reported in this outcome measure. |
| Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 1 | At 20 minutes after tasting specified study formulation on Day 1 | Participants were offered formulation for tasting where they had to swirl sample in their mouth for approximately 10 seconds, and then spit it out. Participant had to assess each sensory attribute on scale of 0 (good) to 100 (bad) after tasting formulation, lower score= better palatability. Following were sensory attributes: mouth feel (grittiness/stickiness or waxiness, 0= normal mouth feel,100=bad mouth feel);bitterness (degree of bitterness of the product, 0= not bitter at all,100= extremely bitter); sweetness(degree of sweet taste,0=sweet, 100= not sweet at all); sourness (degree of sour taste,0= not sour at all,100= extremely sour);saltiness(degree of salty taste,0=not salty at all,100= extremely salty); tongue/mouth burn(degree of tongue/mouth burn,0= no burn at all,100= extreme burn);overall liking (how much like or dislike product, 0= like, 100= dislike).Mean score for each sensory attributes based on palatability assessment questionnaire are reported in this outcome measure. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of Participants With Clinically Significant Laboratory Abnormalities | 1 day prior to first formulation (Day -1) up to last formulation on Day 2 (up to 3 days) | Laboratory analysis included were: hematology, chemistry and urinalysis. Clinically significance in laboratory abnormalities were judged by investigator. |
| Number of Participants With Clinically Significant Vital Signs Abnormalities | Day 1 of receiving formulation up to last formulation on Day 2 (up to 2 days) | Vital signs included blood pressure (systolic and diastolic) and pulse rate. Clinically significance in vital sign abnormalities were judged by investigator. |
| Number of Participants With Treatment Emergent Adverse Events (TEAEs) | Day 1 of receiving formulation up to 35 days after last formulation of the study (up to 37 days) | An AE is any untoward medical occurrence in a participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention. TEAE was an AE that occurred after initiation of study intervention (formulation) that was not present at the time of treatment start up to 35 days after administration of last study intervention (formulation). |
Countries
Belgium
Participant flow
Recruitment details
A total of 12 participants were enrolled in the study.
Pre-assignment details
Participants received sisunatovir prepared in 5 different suspensions (formulation A, B, D, E and F) and bitrex (formulation C as comparator).
Participants by arm
| Arm | Count |
|---|---|
| All Participants All participants who were enrolled and received study intervention in a randomized crossover manner at each period, up to 4 times a day on Day 1 or Day 2. | 12 |
| Total | 12 |
Baseline characteristics
| Characteristic | All Participants |
|---|---|
| Age, Continuous | 47.00 Years STANDARD_DEVIATION 18.95 |
| Ethnicity (NIH/OMB) Hispanic or Latino | 1 Participants |
| Ethnicity (NIH/OMB) Not Hispanic or Latino | 11 Participants |
| Ethnicity (NIH/OMB) Unknown or Not Reported | 0 Participants |
| Race (NIH/OMB) American Indian or Alaska Native | 0 Participants |
| Race (NIH/OMB) Asian | 0 Participants |
| Race (NIH/OMB) Black or African American | 2 Participants |
| Race (NIH/OMB) More than one race | 0 Participants |
| Race (NIH/OMB) Native Hawaiian or Other Pacific Islander | 0 Participants |
| Race (NIH/OMB) Unknown or Not Reported | 0 Participants |
| Race (NIH/OMB) White | 10 Participants |
| Sex: Female, Male Female | 8 Participants |
| Sex: Female, Male Male | 4 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk | EG002 affected / at risk | EG003 affected / at risk | EG004 affected / at risk | EG005 affected / at risk |
|---|---|---|---|---|---|---|
| deaths Total, all-cause mortality | 0 / 12 | 0 / 12 | 0 / 12 | 0 / 12 | 0 / 12 | 0 / 12 |
| other Total, other adverse events | 0 / 12 | 3 / 12 | 0 / 12 | 0 / 12 | 1 / 12 | 0 / 12 |
| serious Total, serious adverse events | 0 / 12 | 0 / 12 | 0 / 12 | 0 / 12 | 0 / 12 | 0 / 12 |
Outcome results
Primary
Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 1
Participants were offered formulation for tasting where they had to swirl sample in their mouth for approximately 10 seconds, and then spit it out. Participant had to assess each sensory attribute on scale of 0 (good) to 100 (bad) after tasting formulation, lower score= better palatability. Following were sensory attributes: mouth feel (grittiness/stickiness or waxiness, 0= normal mouth feel,100=bad mouth feel);bitterness (degree of bitterness of the product, 0= not bitter at all,100= extremely bitter); sweetness(degree of sweet taste,0=sweet, 100= not sweet at all); sourness (degree of sour taste,0= not sour at all,100= extremely sour);saltiness(degree of salty taste,0=not salty at all,100= extremely salty); tongue/mouth burn(degree of tongue/mouth burn,0= no burn at all,100= extreme burn);overall liking (how much like or dislike product, 0= like, 100= dislike).Mean score for each sensory attributes based on palatability assessment questionnaire are reported in this outcome measure.
Time frame: At 10 minutes after tasting specified study formulation on Day 1
Population: Safety analysis set included all participants randomly assigned to study intervention and who took at least 1 dose of study intervention. Data was reported only for those formulations which were administered on Day 1.
| Arm | Measure | Group | Value (MEAN) |
|---|---|---|---|
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 1 | Tongue/Mouth Burn | 23.4 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 1 | Overall Liking | 70.7 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 1 | Sweetness | 23.3 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 1 | Sourness | 42.8 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 1 | Mouth Feel | 62.6 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 1 | Saltiness | 34.6 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 1 | Bitterness | 66.2 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 1 | Bitterness | 48.0 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 1 | Mouth Feel | 43.2 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 1 | Saltiness | 22.3 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 1 | Sweetness | 25.8 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 1 | Sourness | 29.3 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 1 | Tongue/Mouth Burn | 18.8 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 1 | Overall Liking | 53.2 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 1 | Bitterness | 42.0 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 1 | Overall Liking | 42.5 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 1 | Tongue/Mouth Burn | 15.8 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 1 | Sourness | 24.6 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 1 | Sweetness | 16.3 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 1 | Mouth Feel | 40.3 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 1 | Saltiness | 21.1 Units on a scale |
| Formulation D | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 1 | Overall Liking | 51.0 Units on a scale |
| Formulation D | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 1 | Mouth Feel | 44.6 Units on a scale |
| Formulation D | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 1 | Bitterness | 52.7 Units on a scale |
| Formulation D | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 1 | Sweetness | 23.9 Units on a scale |
| Formulation D | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 1 | Sourness | 18.8 Units on a scale |
| Formulation D | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 1 | Saltiness | 22.1 Units on a scale |
| Formulation D | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 1 | Tongue/Mouth Burn | 16.0 Units on a scale |
Primary
Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 2
Participants were offered formulation for tasting where they had to swirl sample in their mouth for approximately 10 seconds, and then spit it out. Participant had to assess each sensory attribute on scale of 0 (good) to 100 (bad) after tasting formulation, lower score= better palatability. Following were sensory attributes: mouth feel (grittiness/stickiness or waxiness, 0= normal mouth feel,100=bad mouth feel);bitterness (degree of bitterness of the product, 0= not bitter at all,100= extremely bitter); sweetness(degree of sweet taste,0=sweet, 100= not sweet at all); sourness (degree of sour taste,0= not sour at all,100= extremely sour);saltiness(degree of salty taste,0=not salty at all,100= extremely salty); tongue/mouth burn(degree of tongue/mouth burn,0= no burn at all,100= extreme burn);overall liking (how much like or dislike product, 0= like, 100= dislike).Mean score for each sensory attributes based on palatability assessment questionnaire are reported in this outcome measure.
Time frame: At 10 minutes after tasting specified study formulation on Day 2
Population: Safety analysis set included all participants randomly assigned to study intervention and who took at least 1 dose of study intervention. Data was reported only for those formulations which were administered on Day 2.
| Arm | Measure | Group | Value (MEAN) |
|---|---|---|---|
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 2 | Bitterness | 56.9 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 2 | Saltiness | 31.5 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 2 | Sourness | 39.7 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 2 | Mouth Feel | 52.5 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 2 | Overall Liking | 59.3 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 2 | Tongue/Mouth Burn | 20.8 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 2 | Sweetness | 20.1 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 2 | Sourness | 29.3 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 2 | Mouth Feel | 39.0 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 2 | Bitterness | 45.1 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 2 | Sweetness | 27.5 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 2 | Saltiness | 20.4 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 2 | Tongue/Mouth Burn | 18.8 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 2 | Overall Liking | 43.2 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 2 | Saltiness | 20.5 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 2 | Bitterness | 42.7 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 2 | Overall Liking | 42.9 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 2 | Tongue/Mouth Burn | 19.0 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 2 | Sourness | 22.8 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 2 | Sweetness | 31.3 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 10 Minutes Post-dose on Day 2 | Mouth Feel | 38.2 Units on a scale |
Primary
Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 1
Participants were offered formulation for tasting where they had to swirl sample in their mouth for approximately 10 seconds, and then spit it out. Participant had to assess each sensory attribute on scale of 0 (good) to 100 (bad) after tasting formulation, lower score= better palatability. Following were sensory attributes: mouth feel (grittiness/stickiness or waxiness, 0= normal mouth feel,100=bad mouth feel);bitterness (degree of bitterness of the product, 0= not bitter at all,100= extremely bitter); sweetness(degree of sweet taste,0=sweet, 100= not sweet at all); sourness (degree of sour taste,0= not sour at all,100= extremely sour);saltiness(degree of salty taste,0=not salty at all,100= extremely salty); tongue/mouth burn(degree of tongue/mouth burn,0= no burn at all,100= extreme burn);overall liking (how much like or dislike product, 0= like, 100= dislike).Mean score for each sensory attributes based on palatability assessment questionnaire are reported in this outcome measure.
Time frame: At 1 minute after tasting specified study formulation on Day 1
Population: Safety analysis set included all participants randomly assigned to study intervention and who took at least 1 dose of study intervention. Data was reported only for those formulations which were administered on Day 1.
| Arm | Measure | Group | Value (MEAN) |
|---|---|---|---|
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 1 | Mouth Feel | 80.3 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 1 | Tongue/Mouth Burn | 27.5 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 1 | Saltiness | 46.6 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 1 | Bitterness | 80.2 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 1 | Overall Liking | 85.1 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 1 | Sweetness | 25.8 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 1 | Sourness | 50.1 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 1 | Tongue/Mouth Burn | 21.3 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 1 | Sourness | 32.8 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 1 | Sweetness | 36.3 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 1 | Saltiness | 28.0 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 1 | Overall Liking | 55.6 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 1 | Bitterness | 49.8 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 1 | Mouth Feel | 49.4 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 1 | Sourness | 32.8 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 1 | Mouth Feel | 54.0 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 1 | Bitterness | 59.5 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 1 | Sweetness | 16.3 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 1 | Saltiness | 26.1 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 1 | Tongue/Mouth Burn | 14.8 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 1 | Overall Liking | 57.9 Units on a scale |
| Formulation D | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 1 | Sweetness | 28.3 Units on a scale |
| Formulation D | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 1 | Overall Liking | 50.4 Units on a scale |
| Formulation D | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 1 | Tongue/Mouth Burn | 18.3 Units on a scale |
| Formulation D | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 1 | Bitterness | 49.4 Units on a scale |
| Formulation D | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 1 | Mouth Feel | 48.5 Units on a scale |
| Formulation D | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 1 | Saltiness | 30.8 Units on a scale |
| Formulation D | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 1 | Sourness | 30.3 Units on a scale |
Primary
Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 2
Participants were offered formulation for tasting where they had to swirl sample in their mouth for approximately 10 seconds, and then spit it out. Participant had to assess each sensory attribute on scale of 0 (good) to 100 (bad) after tasting formulation, lower score= better palatability. Following were sensory attributes: mouth feel (grittiness/stickiness or waxiness, 0= normal mouth feel,100=bad mouth feel);bitterness (degree of bitterness of the product, 0= not bitter at all,100= extremely bitter); sweetness(degree of sweet taste,0=sweet, 100= not sweet at all); sourness (degree of sour taste,0= not sour at all,100= extremely sour);saltiness(degree of salty taste,0=not salty at all,100= extremely salty); tongue/mouth burn(degree of tongue/mouth burn,0= no burn at all,100= extreme burn);overall liking (how much like or dislike product, 0= like, 100= dislike).Mean score for each sensory attributes based on palatability assessment questionnaire are reported in this outcome measure.
Time frame: At 1 minute after tasting specified study formulation on Day 2
Population: Safety analysis set included all participants randomly assigned to study intervention and who took at least 1 dose of study intervention. Data was reported only for those formulations which were administered on Day 2.
| Arm | Measure | Group | Value (MEAN) |
|---|---|---|---|
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 2 | Bitterness | 61.8 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 2 | Saltiness | 41.2 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 2 | Sourness | 36.7 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 2 | Mouth Feel | 61.6 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 2 | Overall Liking | 68.3 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 2 | Tongue/Mouth Burn | 22.8 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 2 | Sweetness | 24.8 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 2 | Sourness | 27.0 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 2 | Mouth Feel | 39.8 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 2 | Bitterness | 43.4 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 2 | Sweetness | 39.3 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 2 | Saltiness | 21.9 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 2 | Tongue/Mouth Burn | 20.2 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 2 | Overall Liking | 42.7 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 2 | Saltiness | 28.0 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 2 | Bitterness | 48.3 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 2 | Overall Liking | 48.3 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 2 | Tongue/Mouth Burn | 20.1 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 2 | Sourness | 28.8 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 2 | Sweetness | 38.3 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 1 Minute Post-dose on Day 2 | Mouth Feel | 46.7 Units on a scale |
Primary
Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 1
Participants were offered formulation for tasting where they had to swirl sample in their mouth for approximately 10 seconds, and then spit it out. Participant had to assess each sensory attribute on scale of 0 (good) to 100 (bad) after tasting formulation, lower score= better palatability. Following were sensory attributes: mouth feel (grittiness/stickiness or waxiness, 0= normal mouth feel,100=bad mouth feel);bitterness (degree of bitterness of the product, 0= not bitter at all,100= extremely bitter); sweetness(degree of sweet taste,0=sweet, 100= not sweet at all); sourness (degree of sour taste,0= not sour at all,100= extremely sour);saltiness(degree of salty taste,0=not salty at all,100= extremely salty); tongue/mouth burn(degree of tongue/mouth burn,0= no burn at all,100= extreme burn);overall liking (how much like or dislike product, 0= like, 100= dislike).Mean score for each sensory attributes based on palatability assessment questionnaire are reported in this outcome measure.
Time frame: At 20 minutes after tasting specified study formulation on Day 1
Population: Safety analysis set included all participants randomly assigned to study intervention and who took at least 1 dose of study intervention. Data was reported only for those formulations which were administered on Day 1.
| Arm | Measure | Group | Value (MEAN) |
|---|---|---|---|
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 1 | Mouth Feel | 58.3 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 1 | Tongue/Mouth Burn | 23.5 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 1 | Saltiness | 33.8 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 1 | Bitterness | 62.7 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 1 | Overall Liking | 69.4 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 1 | Sweetness | 19.1 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 1 | Sourness | 40.4 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 1 | Tongue/Mouth Burn | 16.8 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 1 | Sourness | 26.3 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 1 | Sweetness | 26.6 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 1 | Saltiness | 18.9 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 1 | Overall Liking | 49.4 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 1 | Bitterness | 46.0 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 1 | Mouth Feel | 41.5 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 1 | Sourness | 19.5 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 1 | Mouth Feel | 29.8 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 1 | Bitterness | 24.0 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 1 | Sweetness | 16.5 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 1 | Saltiness | 18.8 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 1 | Tongue/Mouth Burn | 14.8 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 1 | Overall Liking | 34.7 Units on a scale |
| Formulation D | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 1 | Sweetness | 22.0 Units on a scale |
| Formulation D | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 1 | Overall Liking | 46.8 Units on a scale |
| Formulation D | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 1 | Tongue/Mouth Burn | 13.5 Units on a scale |
| Formulation D | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 1 | Bitterness | 47.8 Units on a scale |
| Formulation D | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 1 | Mouth Feel | 44.5 Units on a scale |
| Formulation D | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 1 | Saltiness | 21.3 Units on a scale |
| Formulation D | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 1 | Sourness | 26.3 Units on a scale |
Primary
Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 2
Participants were offered formulation for tasting where they had to swirl sample in their mouth for approximately 10 seconds, and then spit it out. Participant had to assess each sensory attribute on scale of 0 (good) to 100 (bad) after tasting formulation, lower score= better palatability. Following were sensory attributes: mouth feel (grittiness/stickiness or waxiness, 0= normal mouth feel,100=bad mouth feel);bitterness (degree of bitterness of the product, 0= not bitter at all,100= extremely bitter); sweetness(degree of sweet taste,0=sweet, 100= not sweet at all); sourness (degree of sour taste,0= not sour at all,100= extremely sour);saltiness(degree of salty taste,0=not salty at all,100= extremely salty); tongue/mouth burn(degree of tongue/mouth burn,0= no burn at all,100= extreme burn);overall liking (how much like or dislike product, 0= like, 100= dislike).Mean score for each sensory attributes based on palatability assessment questionnaire are reported in this outcome measure.
Time frame: At 20 minutes after tasting specified study formulation on Day 2
Population: Safety analysis set included all participants randomly assigned to study intervention and who took at least 1 dose of study intervention. Data was reported only for those formulations which were administered on Day 2.
| Arm | Measure | Group | Value (MEAN) |
|---|---|---|---|
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 2 | Bitterness | 54.2 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 2 | Saltiness | 32.0 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 2 | Sourness | 39.8 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 2 | Mouth Feel | 48.9 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 2 | Overall Liking | 58.4 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 2 | Tongue/Mouth Burn | 19.6 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 2 | Sweetness | 19.2 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 2 | Sourness | 25.3 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 2 | Mouth Feel | 35.6 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 2 | Bitterness | 40.8 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 2 | Sweetness | 26.2 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 2 | Saltiness | 20.2 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 2 | Tongue/Mouth Burn | 17.6 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 2 | Overall Liking | 42.1 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 2 | Saltiness | 20.1 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 2 | Bitterness | 43.0 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 2 | Overall Liking | 38.3 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 2 | Tongue/Mouth Burn | 18.1 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 2 | Sourness | 23.3 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 2 | Sweetness | 27.4 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 20 Minutes Post-dose on Day 2 | Mouth Feel | 37.1 Units on a scale |
Primary
Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 1
Participants were offered formulation for tasting where they had to swirl sample in their mouth for approximately 10 seconds, and then spit it out. Participant had to assess each sensory attribute on scale of 0 (good) to 100 (bad) after tasting formulation, lower score= better palatability. Following were sensory attributes: mouth feel (grittiness/stickiness or waxiness, 0= normal mouth feel,100=bad mouth feel);bitterness (degree of bitterness of the product, 0= not bitter at all,100= extremely bitter); sweetness(degree of sweet taste,0=sweet, 100= not sweet at all); sourness (degree of sour taste,0= not sour at all,100= extremely sour);saltiness(degree of salty taste,0=not salty at all,100= extremely salty); tongue/mouth burn(degree of tongue/mouth burn,0= no burn at all,100= extreme burn);overall liking (how much like or dislike product, 0= like, 100= dislike).Mean score for each sensory attributes based on palatability assessment questionnaire are reported in this outcome measure.
Time frame: At 5 minutes after tasting specified study formulation on Day 1
Population: Safety analysis set included all participants randomly assigned to study intervention and who took at least 1 dose of study intervention. Data was reported only for those formulations which were administered on Day 1.
| Arm | Measure | Group | Value (MEAN) |
|---|---|---|---|
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 1 | Mouth Feel | 66.6 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 1 | Tongue/Mouth Burn | 23.3 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 1 | Saltiness | 34.5 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 1 | Bitterness | 72.3 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 1 | Overall Liking | 78.3 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 1 | Sweetness | 22.7 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 1 | Sourness | 43.8 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 1 | Tongue/Mouth Burn | 21.8 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 1 | Sourness | 30.3 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 1 | Sweetness | 30.3 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 1 | Saltiness | 23.0 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 1 | Overall Liking | 53.3 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 1 | Bitterness | 45.9 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 1 | Mouth Feel | 45.8 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 1 | Sourness | 28.9 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 1 | Mouth Feel | 50.9 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 1 | Bitterness | 53.5 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 1 | Sweetness | 18.3 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 1 | Saltiness | 24.9 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 1 | Tongue/Mouth Burn | 17.1 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 1 | Overall Liking | 52.3 Units on a scale |
| Formulation D | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 1 | Sweetness | 27.4 Units on a scale |
| Formulation D | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 1 | Overall Liking | 49.4 Units on a scale |
| Formulation D | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 1 | Tongue/Mouth Burn | 17.3 Units on a scale |
| Formulation D | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 1 | Bitterness | 53.2 Units on a scale |
| Formulation D | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 1 | Mouth Feel | 46.7 Units on a scale |
| Formulation D | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 1 | Saltiness | 24.5 Units on a scale |
| Formulation D | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 1 | Sourness | 27.7 Units on a scale |
Primary
Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 2
Participants were offered formulation for tasting where they had to swirl sample in their mouth for approximately 10 seconds, and then spit it out. Participant had to assess each sensory attribute on scale of 0 (good) to 100 (bad) after tasting formulation, lower score= better palatability. Following were sensory attributes: mouth feel (grittiness/stickiness or waxiness, 0= normal mouth feel,100=bad mouth feel);bitterness (degree of bitterness of the product, 0= not bitter at all,100= extremely bitter); sweetness(degree of sweet taste,0=sweet, 100= not sweet at all); sourness (degree of sour taste,0= not sour at all,100= extremely sour);saltiness(degree of salty taste,0=not salty at all,100= extremely salty); tongue/mouth burn(degree of tongue/mouth burn,0= no burn at all,100= extreme burn);overall liking (how much like or dislike product, 0= like, 100= dislike).Mean score for each sensory attributes based on palatability assessment questionnaire are reported in this outcome measure.
Time frame: At 5 minutes after tasting specified study formulation on Day 2
Population: Safety analysis set included all participants randomly assigned to study intervention and who took at least 1 dose of study intervention. Data was reported only for those formulations which were administered on Day 2.
| Arm | Measure | Group | Value (MEAN) |
|---|---|---|---|
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 2 | Bitterness | 61.2 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 2 | Saltiness | 33.6 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 2 | Sourness | 41.0 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 2 | Mouth Feel | 53.3 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 2 | Overall Liking | 62.5 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 2 | Tongue/Mouth Burn | 20.3 Units on a scale |
| Formulation A | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 2 | Sweetness | 21.7 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 2 | Sourness | 26.8 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 2 | Mouth Feel | 38.4 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 2 | Bitterness | 46.7 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 2 | Sweetness | 29.5 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 2 | Saltiness | 22.3 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 2 | Tongue/Mouth Burn | 19.6 Units on a scale |
| Formulation B | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 2 | Overall Liking | 43.0 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 2 | Saltiness | 22.7 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 2 | Bitterness | 48.7 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 2 | Overall Liking | 44.3 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 2 | Tongue/Mouth Burn | 19.7 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 2 | Sourness | 26.9 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 2 | Sweetness | 32.8 Units on a scale |
| Formulation C | Mean Score of Sensory Attributes Based on Palatability Assessment Questionnaire at 5 Minutes Post-dose on Day 2 | Mouth Feel | 42.3 Units on a scale |
Secondary
Number of Participants With Clinically Significant Laboratory Abnormalities
Laboratory analysis included were: hematology, chemistry and urinalysis. Clinically significance in laboratory abnormalities were judged by investigator.
Time frame: 1 day prior to first formulation (Day -1) up to last formulation on Day 2 (up to 3 days)
Population: Safety analysis set included all participants randomly assigned to study intervention and who took at least 1 dose of study intervention. Participants were analyzed according to the product they actually received.
| Arm | Measure | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|
| Formulation A | Number of Participants With Clinically Significant Laboratory Abnormalities | 0 Participants |
| Formulation B | Number of Participants With Clinically Significant Laboratory Abnormalities | 0 Participants |
| Formulation C | Number of Participants With Clinically Significant Laboratory Abnormalities | 0 Participants |
| Formulation D | Number of Participants With Clinically Significant Laboratory Abnormalities | 0 Participants |
| Formulation E | Number of Participants With Clinically Significant Laboratory Abnormalities | 0 Participants |
| Formulation F | Number of Participants With Clinically Significant Laboratory Abnormalities | 0 Participants |
Secondary
Number of Participants With Clinically Significant Vital Signs Abnormalities
Vital signs included blood pressure (systolic and diastolic) and pulse rate. Clinically significance in vital sign abnormalities were judged by investigator.
Time frame: Day 1 of receiving formulation up to last formulation on Day 2 (up to 2 days)
Population: Safety analysis set included all participants randomly assigned to study intervention and who took at least 1 dose of study intervention. Participants were analyzed according to the product they actually received.
| Arm | Measure | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|
| Formulation A | Number of Participants With Clinically Significant Vital Signs Abnormalities | 0 Participants |
| Formulation B | Number of Participants With Clinically Significant Vital Signs Abnormalities | 0 Participants |
| Formulation C | Number of Participants With Clinically Significant Vital Signs Abnormalities | 0 Participants |
| Formulation D | Number of Participants With Clinically Significant Vital Signs Abnormalities | 0 Participants |
| Formulation E | Number of Participants With Clinically Significant Vital Signs Abnormalities | 0 Participants |
| Formulation F | Number of Participants With Clinically Significant Vital Signs Abnormalities | 0 Participants |
Secondary
Number of Participants With Treatment Emergent Adverse Events (TEAEs)
An AE is any untoward medical occurrence in a participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention. TEAE was an AE that occurred after initiation of study intervention (formulation) that was not present at the time of treatment start up to 35 days after administration of last study intervention (formulation).
Time frame: Day 1 of receiving formulation up to 35 days after last formulation of the study (up to 37 days)
Population: Safety analysis set included all participants randomly assigned to study intervention and who took at least 1 dose of study intervention. Participants were analyzed according to the product they actually received.
| Arm | Measure | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|
| Formulation A | Number of Participants With Treatment Emergent Adverse Events (TEAEs) | 0 Participants |
| Formulation B | Number of Participants With Treatment Emergent Adverse Events (TEAEs) | 3 Participants |
| Formulation C | Number of Participants With Treatment Emergent Adverse Events (TEAEs) | 0 Participants |
| Formulation D | Number of Participants With Treatment Emergent Adverse Events (TEAEs) | 0 Participants |
| Formulation E | Number of Participants With Treatment Emergent Adverse Events (TEAEs) | 1 Participants |
| Formulation F | Number of Participants With Treatment Emergent Adverse Events (TEAEs) | 0 Participants |