Dermatomyositis, Inflammation, Myocardial Repolarization
Conditions
Brief summary
The goal of this observational study is to investigate ventricular repolarization utilizing Tp-e intervals and Tp-e/QT ratios in patients with DM. The main questions it aims to answer are: * 1.Exploring the changes in ventricular repolarization parameters (QT interval, QTc interval, QTd, Tp-e interval, Tp-e/QT ratio) in patients with dermatomyositis, providing quantifiable indicators for early detection of arrhythmia in dermatomyositis patients; * 2.Exploring the role of inflammation in ventricular repolarization in DM patients, providing a basis for in-depth research on the diagnosis and prevention of arrhythmia in DM patients.
Interventions
OTHERdisease
Do you have dermatomyositis
Sponsors
The Third People's Hospital of Hangzhou
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
Regardless of gender, registered residence and education level, voluntarily participate in this study and sign the informed consent form. Clinical diagnosis of Dermatomyositis.
Exclusion criteria
Previous history of heart disease (such as myocardial infarction, cardiac pacing, congenital heart disease, ischemic heart disease, etc.), chronic kidney disease, etc; Patients with other connective tissue diseases; Pregnant and lactating women. Taking drugs that affect electrocardiogram indicators, such as macrolides, quinolones, quinidine, amiodarone, antipsychotic drugs, etc. Patients with severe lack of case data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QTc, Tp-e interval, and Tp-e/QT ratio were increased in DM patients. | November 2011 to November 2022 |
| the Tp-e interval and Tp-e/QT ratio were positively correlated with Inflammation. | November 2011 to November 2022 |
Countries
China
Outcome results
None listed