Peutz-Jeghers Syndrome, Small Bowel Polyp
Conditions
Brief summary
This study aims to evaluate the feasibility and safety of Cold snare polypectomy for removing 5-9mm small intestinal polyps in patients with Peutz-Jeghers Syndrome (PJS),in order to provide some reference for clinical strategy of endoscopic treatment of small intestinal polyps in PJS patients, and may prolong the follow-up period of PJS patients Intervals.
Interventions
PROCEDURECold snare polypectomy
For eligible patients, use cold snare polypectomy to resect 5-9mm short-pedicled, broad-pedicled or sessile small bowel polyps
Sponsors
Shandong University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
8 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Age 8-60, male or female. * Diagnosed with Peutz-Jeghers Syndrome * Undergo enteroscopy for small bowel polypectomy.
Exclusion criteria
* Absence of at least one study polyp (5-9mm stubby pedicle, wide pedicle and sessile small bowel polyps); * Be evaluated during enteroscopy for requiring surgical intervention (such as endoscopically difficult to handle giant polyps, intussusception, etc.)； * With more than 50 polyps ≥1cm found in this enteroscopy examination; * The polyp has been confirmed to be malignant by pathology, or highly suspicious of malignant transformation under endoscopy; * Receiving anticoagulant therapy during this treatment; * Unable or unwilling to provide informed consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of complications in the application of cold snare polypectomy for 5-9mm small bowel polypectomy in patients with PJS | 28 days after the procedure | The complications include complications during CSP and complications occurring within 28 days after enteroscopy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of complications during cold snare polypectomy for 5-9mm small bowel polypectomy | Immediately after the procedure | Including intraoperative bleeding (defined as active haemorrhage for more than 30s), perforation immediately, etc. |
| Incidence of complications within 28 days after enteroscopy | 28 days after the procedure | Including Delayed bleeding, delayed perforation, pancreatitis, electrocoagulation syndrome. |
Countries
China
Outcome results
None listed