Glioblastoma
Conditions
Keywords
glioblastoma, CD146, bevacizumab
Brief summary
Glioblastoma is the most common malignant primary brain tumor with poor prognosis because of its diffusive and infiltrative nature. The FDA approved the use of the anti-VEGF antibody bevacizumab in recurrent GBM. However, resistance to this anti-angiogenic reagent is frequent and fails to enhance patients' overall survival. The investigators previously identified one novel mechanism responsible for bevacizumab-resistance in CD146-positive glioblastoma (Joshkon et al. Acta Neuropathol Commun, 2022). Now, the investigators objective is to prospectively monitor the soluble CD146 value in plasma from patients treated by bevacizumab for recurrent glioblastoma. The investigators will collect plasma at baseline, before the first bevacizumab administration, before the second administration, at the time of first MRI evaluation and at progression. Plasma CD146 value will be analyzed by ELISA. The investigators expect to confirm the correlation between soluble CD146 value in plasma and patient response to bevacizumab.
Interventions
OTHERplasma collection
Plasma samples will be prospectively collected at relevant time points during patient treatment.
Sponsors
Assistance Publique Hopitaux De Marseille
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* \- Adult patients with recurrent IDHwt glioblastoma * Relapse after standard first line treatment (radio-chemotherapy) * Candidate for bevacizumab treatment * Able to be monitored by MRI * KPS ≥ 60% * Written signed consent form
Exclusion criteria
* Pregnancy or breast feeding * Life expectancy less than 3 months * Bevacizumab in first line treatment * Other concomitant life-threatening disease * Under legal protection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| correlation between soluble CD146 plasma value and patient response (RANO) | first evaluation (2 months) | Soluble CD146 plasma value will be assessed using ELISA. Patient response will be evaluated by MRI and clinical response using the international RANO criteria. |
Countries
France
Contacts
Primary ContactEmeline Tabouret
Backup ContactDRSMR AP-HM
Outcome results
None listed