The Influence of Oral Probiotic on the Vaginal Flora and Microenvironment Alteration in the Vaginosis Infection Women

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06001190

Enrollment

Registered

2023-08-21

Start date

2023-07-15

Completion date

2024-03-30

Last updated

2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Probiotic, Human Papillomavirus Infection, Pap Smear, Microbiome

Brief summary

A single-blind, randomized, and probiotic-treatment including adult women with vaginitis and/or HPV positive. After oral probiotics, all participants will be followd-up cervical swabs and vaginal microbiome alteration till the end of the study.

Interventions

DIETARY_SUPPLEMENTprobiotic:Lactobacillus crispatus

We seek to observe that probiotic supplement(arm A) can improve vagina microbiome distribution by comapred to placebo group(arm B) in our study.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

DOUBLE (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

* diagnosed as vaginal viginitis * willing to sign permit * willing to regular follow up

Exclusion criteria

* Pregnant * Virgin * Severe cervix pathology CINII or CIN III * Confirmed cervical cancer * under long term antibiotics due to other physical condition

Design outcomes

Primary

Measure	Time frame	Description
improvement alteration of vaginal microbiome	3 months	16s rRNA

Countries

Taiwan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026