Aortic Dissection, Arrhythmias, Cardiac, Brain Neoplasms, Cardiomyopathies, Coronary Artery Disease, Heart Neoplasms, Heart Valve Diseases, Hemorrhagic Cerebrovascular Disease, Hypertension, Ischemic Cerebrovascular Disease, Myocarditis, Structural Heart Disease
Conditions
Keywords
Cardiovascular diseases, Cerebrovascular diseases, Prognosis, Multi-omics
Brief summary
The etiology and specific pathogenesis of many cardiovascular diseases such as coronary atherosclerosis, cardiomyopathy, atrial fibrillation, and stroke are still unclear. Improving diagnosis and treatment, clarifying the pathogenesis, and providing scientific basis for the prevention and treatment are hot research topics in the study of cardiovascular and cerebrovascular diseases. This study intends to collect clinical data and biological specimen data of patients with cardiovascular and cerebrovascular diseases who meet the inclusion and exclusion criteria, and use multi-omics technology to deeply understand the pathogenic mechanisms of cardiovascular and cerebrovascular diseases and provide new ideas for specific and individualized treatment of patients with cardiovascular and cerebrovascular diseases, to construct early predictive prognostic models and provide a basis for effective treatment of clinical practice in patients with cardiovascular and cerebrovascular diseases.
Detailed description
Cardiovascular and cerebrovascular diseases refer to ischemic and hemorrhagic diseases of the heart, brain and body tissues caused by hyperlipidemia, blood viscosity, atherosclerosis, hypertension, etc. It is one of the major public health problems in the world. The etiology and specific pathogenesis of many cardiovascular diseases such as coronary atherosclerosis, cardiomyopathy, atrial fibrillation, and stroke are still unclear. Improving diagnosis and treatment, clarifying the pathogenesis, and providing scientific basis for the prevention and treatment are hot research topics in the study of cardiovascular and cerebrovascular diseases. This study intends to collect clinical data and biological specimen data of patients with cardiovascular and cerebrovascular diseases who meet the inclusion and exclusion criteria, and use multi-omics technology to deeply understand the pathogenic mechanisms of cardiovascular and cerebrovascular diseases and provide new ideas for specific and individualized treatment of patients with cardiovascular and cerebrovascular diseases, to construct early predictive prognostic models and provide a basis for effective treatment of clinical practice in patients with cardiovascular and cerebrovascular diseases.
Interventions
Observational; No Interventions were given.
Sponsors
Xi'an Gaoxin Hospital
First Affiliated Hospital of Chongqing Medical University
General Hospital of Ningxia Medical University
Second Affiliated Hospital of Nanchang University
First Affiliated Hospital Xi'an Jiaotong University
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
3 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients who are regularly visited and followed up in the appropriate patient; department. * All patients met at least one of the following diagnostic criteria for cardiovascular and cerebrovascular diseases: * coronary artery disease group; * arrhythmia group; * heart valve disease group; * aortic dissection group; * cardiac masses group; * myocarditis group; * hypertension group; * cardiomyopathy group; * structural heart disease group; * ischemic cerebrovascular disease group; * hemorrhagic cerebrovascular disease group; * intracranial space occupying lesion group.
Exclusion criteria
* Age \<3 years or \>80 years old; * Pregnant and lactating women; * The patient declined to provide informed consent to participate in the study; * None of the above was met, but the patient was temporarily unable to sign the informed consent form due to coma and other reasons, and no legal representative signed it instead. Depending on the patient's condition, the patient may not be able to regain consciousness and sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of MACCE | Through study completion, up to 5 years. | Major adverse cardiovascular and cerebrovascular events, a composite of all-cause mortality, myocardial infarction, coronary revascularization, and stroke. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of all-cause mortality | Through study completion, up to 5 years. | Incidence of patients' death from any cause. |
| Incidence of myocardial infarction | Through study completion, up to 5 years. | Changes of serum myocardial zymogram level and ECG were used for diagnosing of myocardial infarction. |
| Incidence of coronary revascularization. | Through study completion, up to 5 years. | Incidence of percutaneous coronary intervention or coronary artery bypass grafting. |
| Incidence of stroke | Through study completion, up to 5 years. | Stroke were assessed by radiologist using CT scan or other imaging test. |
Countries
China
Contacts
Primary ContactGouliang Li
Backup ContactYang Yan
Outcome results
None listed