Knee Osteoarthritis
Conditions
Keywords
knee osteoarthritis, knee chondromalacia
Brief summary
clinical efficacy of autologous stromal vascular fraction SVF,for inflammatory and degenerative conditions of the knees
Detailed description
to evaluate the clinical effectiveness of point of care autologous adipose derived stromal vascular fraction (SVF) alone or in combination with exosomes,for inflammatory and degenerative conditions of the knees.
Interventions
PROCEDUREstromal vascular fraction injection in the osteoarthritic knee
stromal vascular fraction harvested from mid abdominal wall under sedation and seperated from fat using mechanical centrifugation .injection of 5 cc of the SVF in the affected knee.
Sponsors
Dubai Health Authority
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Masking description
investigator is blinded to clinical and radiological assessments .
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* knee osteoarthritis any grade * knee chondromalacia grade 2 and above
Exclusion criteria
* active HIV * pregnant women * Mental disease * severe cardio vascular disease * severe coagulation disorders * infected tissues * patients on other experimental studies within 3 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change in pain level | 2 years | visual analog scale 0-10 ( 10 being worst) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| percentage cartilage thickness change | 2 years | as measured by MRI |
Contacts
Primary ContactAmer Mansour, MD
Backup Contactmazen sawaf, MD
Outcome results
None listed