Juvenile Recurrent Respiratory Papillomatosis
Conditions
Brief summary
Recurrent respiratory papillomatosis (RRP) is a rare disease. However, it is the most common benign laryngeal tumor in children. To date, no epidemiological data are available in France. The aim of this study is to establish the epidemiology of juvenile PPR.
Detailed description
Recurrent respiratory papillomatosis (RRP) is characterized by the recurrent proliferation of multiple polypoid squamous tumors in the respiratory tract, linked to HPV infection. RRP is a rare disease. However, it is the most common benign laryngeal tumor in children. There are currently no French national epidemiological data on this disease. The data collected by the reference centers will enable us to gain a better understanding of this pathology in terms of epidemiology, risk factors, genetic susceptibility and clinical manifestations, as well as to significantly study the efficacy of the various existing therapies and preventive measures, in order to establish a clear, standardized and optimal guideline.
Interventions
None listed
Sponsors
Imagine Institute
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients with juvenile PRR (disease onset before age 18) * Followed in the : * The MALO CRMR * One of the MALO network's CCMRs * One of the main correspondent centers
Exclusion criteria
* Patients objecting to the collection of their personal data * Parents of minor patients objecting to the collection of their child's personal data
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Epidemiology of juvenile RRP in France by clinical information | 10 years | age at onset of disease, symptoms, severity score, intensity of disease characterized by need for endoscopies |
| Epidemiology of juvenile PRR in France according to vaccine and adjuvant therapeutic information | 10 years | Vaccination and adjuvant therapy information |
| Epidemiology of juvenile PRR in France by paraclinical information | 10 years | results of pulmonary imaging, genetic, anatomopathological and immunological tests |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Define standardized management of juvenile RRP | 10 years | Correlations between disease progression and frequency of follow-up, as well as treatments implemented (therapeutic or surgical interventions) |
| Therapeutic management of RRP | 10 years | * Frequency of therapeutic surgery * Use of adjuvant therapies |
| Prevention of RRP | 10 years | Analysis of national vaccination coverage with a vaccine immunizing against HPV 6 and 11 |
Countries
France
Contacts
Primary ContactNicolas LEBOULANGER, MD
Outcome results
None listed