The Application of the New Magnetic Resonance UTE Technique in Thoracic Lesions

The Application of the New Magnetic Resonance Technique-UTE in Thoracic Lesions

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05998707

Enrollment

150

Registered

2023-08-21

Start date

2023-07-01

Completion date

2024-06-13

Last updated

2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Diseases

Keywords

Lung mass, UTE, ZTE, nodule, MRI

Brief summary

Quantitative characteristic values of lung lesions were obtained by UTE technique, so as to make qualitative diagnosis of benign and malignant lesions. And to explore the clinical feasibility of CT-like technology - high resolution ZTE technology in the diagnosis of pulmonary diseases.

Detailed description

Ultrashort echo time (UTE) sequence can obtain data from T2\* for lung imaging before T2\* decays in lung parenchyma with extremely short echo time, which makes up for the defect that conventional MRI cannot clearly display short T2 tissue imaging, and can provide more supplementary information for lung CT scan. There has been a lot of research progress in the evaluation of neonatal lung disease, chronic obstructive airway disease and pneumonia. The 3D UTE sequence developed on this basis has made great progress in improving the resolution, signal-to-noise ratio and shortening the scanning time of lung MR Images, and has successfully obtained submillimeter high-resolution images. The purpose of this study was to explore the value of MRI ultra-short echo technology in the qualitative diagnosis of benign and malignant lung lesions, and to explore the clinical application of CT-like technology - high resolution ZTE technology in the lung.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Age ≥18 years old; 2. There are lung lesions, and the solid component is ≥6mm; 3. Chest CT plain scan or /+ enhanced examination within 4 weeks.

Exclusion criteria

1. There are metal implants in the corresponding parts of the chest; 2. MRI contrast agent allergy; 3. Claustrophobia; 4. Pregnant women; 5. High fever; 6. Respiratory failure; 7. Lung lesion biopsy within 4 weeks prior to examination.

Design outcomes

Primary

Measure	Time frame	Description
proton density fat fraction (PDFF)	baseline (before surgery)	Determination of proton density fat fraction by magnetic resonance imaging
T2 relaxation rate	baseline (before surgery)	R2\*
Magnetization Transfer Ratio (MTR)	baseline (before surgery)	Magnetization Transfer Ratio

Secondary

Measure	Time frame	Description
Subjective rating	baseline (before surgery)	rating scale

Countries

China

Contacts

Primary ContactXiaojun Chen

422175400@qq.com+8615820587112

Outcome results