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Characterization of Dynamic Stability in Normal Pressure Hydrocephalus and Parkinson's Disease

Characterization of Dynamic Stability in Normal Pressure Hydrocephalus and Parkinson's Disease

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05998473
Acronym
HPGAIT
Enrollment
150
Registered
2023-08-21
Start date
2023-06-01
Completion date
2023-12-31
Last updated
2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diagnoses Disease, Gait Ataxia, Hydrocephalus, Movement Disorders, Parkinson Disease, Walking, Difficulty

Brief summary

This study aims to characterize dynamic stability disorders in two conditions mainly affecting the elderly and with similar walking deficits: hydrocephalus at normal pressure and Parkinson's disease, to provide the most relevant monitoring criteria in usual care.

Detailed description

Walking disorders in normal pressure hydrocephalus are manifested by slowing and ataxic gait, similar to disorders in Parkinson's disease. No studies in the literature have focused on advanced measures of dynamic stability in hydrocephalus at normal pressure, compared to Parkinson's disease, on large samples. The Laboratory of Analysis and Restoration of Movement, located in a Neurorehabilitation Department, provides quantitative data on gait and in particular dynamic stability as part of additional assessments to help patients follow up. Since 2010, people with normal pressure hydrocephalus or Parkinson's disease regularly benefit from these assessments. Retrospective analysis of all these data would help to better characterize motor disorders in hydrocephalus at normal pressure, by discriminating them from those associated with Parkinson's disease. It would lead to the definition of relevant indices to be used for patient follow-up.

Interventions

The subject is asked to walk 8 meters 3 times: at free speed, at fast speed, and with large steps.

Sponsors

Henri Mondor University Hospital
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
Yes

Inclusion criteria

* Age \>18 years * Patient who performed a walking test in the Laboratory Analysis and Restoration of Movement * Diagnosis of normal pressure hydrocephalus or Parkinson's disease

Exclusion criteria

* Levodopa drugs administrated during a delay of 12 hours before walking test * Presence of an other neurologic disease or of any disease associated with motor disorders in lower limb.

Design outcomes

Primary

MeasureTime frameDescription
Coefficient of variation in step length30 secondsCoefficient of variation in step length during 8-meter comfortable walking test

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026