Oral Lichen Planus
Conditions
Keywords
oral lichen planus, depression, anxiety, mesenchymal stem cells
Brief summary
Oral lichen planus (OLP) is a common chronic inflammatory disease of Oral mucosa. The pathogenesis of OLP is not clear, and there is no effective method to cure it. In vitro, previous studies have shown that oral mucosal mesenchymal stem cell cells (MSCs) can secrete Ido, which is involved in the pathogenesis of OLP. It has been proved that mental disorders such as depression and anxiety play an important role in the pathogenesis and treatment of OLP. Mental stress factors can cause abnormal changes of inflammatory factors, leading to immune dysfunction, which is also one of the main causes of OLP. In this study, we integrated the advantages of stomatology, psychiatry, neurobiology and traditional Chinese medicine, focused on the clinical problems of mental disorders with oral mucosal comorbidity, and assessed the depressive and anxiety status of OLP patients, so as to improve the therapeutic effect of OLP.
Interventions
OTHERControl
Investigation of scale of control
OTHERNon erosive OLP
Investigation of cale of non erosive OLP patients
OTHERErosive OLP
Investigation of cale of erosive OLP patients
Sponsors
Peking University Third Hospital
Study design
Observational model
CASE_CROSSOVER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* patients with oral lichen planus * male or female patients older than 18 years of age * patients willing to participate with signed informed consent.
Exclusion criteria
* pregnant or lactating * had serious systemic diseases of the heart, lung, liver, and kidney, or had tumors * were unwilling to participate in the experiment.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The scores of the scale with the symptoms and signs of the disease | During the initial diagnosis，through study completion, an average of 1 year | Psychological factors in OLP patients and normal controls were assessed using psychological scales such as the Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD). Tissue and blood samples were collected during visits, and the concentrations of inflammatory factors in normal and lesion tissues were detected using immunofluorescence, flow cytometry, and enzyme-linked immunosorbent assay (ELISA). Statistical analysis was performed to determine the correlation between emotional disorders and inflammation in OLP patients, aiming to elucidate the underlying pathogenic mechanisms. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Immune inflammatory response | During the initial diagnosis，through study completion, an average of 1 year | Psychological factors in OLP patients and normal controls were assessed using psychological scales such as the Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD). Tissue and blood samples were collected during visits, and the concentrations of inflammatory factors in normal and lesion tissues were detected using immunofluorescence, flow cytometry, and enzyme-linked immunosorbent assay (ELISA). Statistical analysis was performed to determine the correlation between emotional disorders and inflammation in OLP patients, aiming to elucidate the underlying pathogenic mechanisms. |
Countries
China
Contacts
Primary ContactZhihui Zhang
Backup ContactLin Zeng
Outcome results
None listed