Major Trauma
Conditions
Keywords
major trauma, arterial line, resuscitation
Brief summary
Accident-related deaths is the 7th leading cause of death in Taiwan, and most of them is due to trauma from falls and traffic accident. Among trauma patients, the common cause of death is from hemorrhagic shock. Thus, real-time and accurate blood pressure monitoring is important for trauma patients. Incorrect blood pressure monitoring can lead to adverse events like traumatic cardiac arrest and shock and can also delay the time for intervention (fluid resuscitation, blood transfusion and operation). The current practice of blood pressure monitoring in trauma patient is by non-invasive blood pressure monitoring, which may be incorrect and not timely. Patient's body type and peripheral perfusion can both influence the result of non-invasive blood pressure monitoring. With continuous and correct blood pressure monitoring, the resuscitation team can give adequate and timely treatment. In some trauma centers, arterial line insertion in trauma patients is a daily practice, while the evidence is inadequate and the potential benefit in unknown. The main purpose of this study is to investigate the application of arterial line insertion in trauma patients. The study design is a prospective before-after study to exam whether arterial line insertion in trauma patients can reduce adverse event rate like hypovolemic shock and improve patient's outcomes.
Interventions
DEVICEarterial line
insert arterial line for patients who meet major trauma criteria
Sponsors
National Taiwan University Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Intervention model description
We use se before-after study type and only the after phase receive intervention. Before phase will retrospectively collect data from patient without arterial line intervention.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Glasgow Coma Scale (GCS) 13 or less * SBP \< 90 mmHg * Respiratory rate \< 10 or \> 29 breaths/min * Fall from height \> 6 meters * High-Risk Auto Crash: Partial or complete ejection, intrusion \> 30 cm any site, Need for extrication for entrapped patient, Death in passenger compartment * Rider separated from transport vehicle with significant impact * Penetrating injuries to head, neck, torso, and proximal extremities * Skull deformity, suspected skull fracture * Chest wall instability, deformity, or suspected flail chest * Suspected pelvic fracture * Suspected fracture of two or more proximal long bones * Amputation proximal to wrist or ankle * Active bleeding requiring a tourniquet or wound packing with continuous pressure * Burns in conjunction with trauma
Exclusion criteria
* Pregnancy * Patient or family who are unable to obtain informed consent * Known coagulopathy that is inappropriate for arterial line insertion * Known peripheral arterial occlusion disease that is inappropriate for arterial line insertion * traumatic cardiac arrest
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| composite primary endpoint (including any hypotension, vasopressors usage, any cardiac arrest in ER, Shock index ) | during ER stay, up to 6 hours | including any hypotension, vasopressors usage, any cardiac arrest in ER, Shock index (HR/SBP)\>1 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 30 days mortality rate | mortality within 30 days of trauma event | mortality within 30 days of trauma event |
| volume of fluid administration | during ER stay, up to 6 hours | any type of fluid administration |
| prolong ICU admission | up to 7 days | define as \> 6 days of admission |
| units of red blood cell transfusion | during ER stay, up to 6 hours | units of red blood cell transfusion |
| arterial blood pressure trajectory | during ER stay, up to 6 hours | We will depict the arterial blood pressure trajectory for each patient. |
| Area under curve (AUC) difference under different time measuring frequency | 1/3/5/10 minutes | We will use continuous blood pressure data and apply different intervals (1, 3, 5, and 10 minutes) to create a plot, then smooth it to calculate the area under the curve (AUC). |
Countries
Taiwan
Outcome results
None listed