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Effects Of Caffeine On Cognitive Performance

Effects Of Different Doses Of Caffeine On Cognitive Performance In Healthy Physically Active Individuals

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05995314
Enrollment
30
Registered
2023-08-16
Start date
2023-08-07
Completion date
2023-09-04
Last updated
2023-09-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Caffeine

Keywords

ergogenic aid, sport performance, reaction time, anticipation, attention, memory

Brief summary

Caffeine is a potent central nervous system stimulant that increases the activity in the prefrontal cortex and can improve cognitive skills. An improvement in these cognitive skills can lead to further benefits in athletic performance. Therefore, it is necessary to clarify the dose-response of caffeine on cognitive performance.The aim of this research will be to determine the effects of different doses of caffeine on sport-related cognitive aspects.

Detailed description

The investigators will require healthy, physically active young adults to complete three trials under the conditions: a) placebo, b) 3 mg/kg, or c) 6 mg/kg body mass of caffeine. In each trial, different cognitive abilities will be assessed using the following test batteries: reaction time (DynavisionTM D2), anticipation (Bassin Anticipation Timer), sustained attention (Go/No-Go and Eriksen Flanker Test) and memory tests. In addition, side effects and the perceived sensation index will be recorded 24 h after each test.

Interventions

DIETARY_SUPPLEMENTPLACEBO

3 mg/kg of cellulose (0 mg/kg of caffeine)

DIETARY_SUPPLEMENT3 mg/kg of caffeine

Ingestion of 3 mg/kg of body mass of caffeine

DIETARY_SUPPLEMENT6 mg/kg of caffeine

Ingestion of 6 mg/kg of body mass of caffeine

Sponsors

University of Castilla-La Mancha
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)

Masking description

To achieve the blinded placebo situation, a researcher not associated with the study will be performed the blinding and prepared identical capsules containing placebo or the corresponding dose of caffeine. This researcher will be assigned an alphanumeric code to each trial to blind participants and investigators

Eligibility

Sex/Gender
ALL
Age
18 Years to 30 Years
Healthy volunteers
Yes

Inclusion criteria

* Physically active individuals ( \>150 min/week moderate physical activity or \>75 min/week vigorous physical activity) * Individuals without serious and undiagnosed health problems.

Exclusion criteria

* Individuals with color blindness. * Regular caffeine consumers (\>3 cups of coffee/day).

Design outcomes

Primary

MeasureTime frameDescription
Reaction Time10 minutesReaction time (in seconds) shall be assessed with the Dynavision™ D2 Visomotor Device using the Reaction Time Test. In this test the fastest visual, motor and physical reaction time will be measured.
Anticipation5 minutesVisual acuity related to hand-eye coordination and anticipation will be assessed using the Bassin Anticipation Timer instrument. The best anticipation time (in seconds) of each condition (5, 10 and 15 mph) will be taken.
Sustained attention10 minutesThe ability of maintaining the attention and inhibiting an appropriate response will be measured by Go/No-Go Test \[fastest, slowest, and average response time (in seconds), and successful attempts (percentage; %)\] and Eriksen Flanker Test \[congruent and incongruent reaction time (in seconds)\].
Memory20 minutesTo study the modulation of memory storage processes, three 20-item word lists were created. Each word in the list will be presented for 5 s. This will be followed by a 100 s memory consolidation interval, after which there will be a 120 s period in which as many words as the participants can remember will be written down (First time). After 15 min, participants will perform a recall task (Second time) in which they will have to rewrite all the words they remember at that time.

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 6, 2026