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Homeopathic Treatment of Children Suffering From PFAPA

Homeopathic Treatment of Children Suffering From PFAPA: a Retrospective Case Series.

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05995288
Acronym
HOMPFAPA
Enrollment
13
Registered
2023-08-16
Start date
2019-05-01
Completion date
2023-08-08
Last updated
2023-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodic Fever Syndrome

Keywords

PFAPA, periodic fever, homeopathy, Naranjo criteria

Brief summary

Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome is frequently diagnosed in young children. Fevers recurring at a nearly predictable rate every three to eight weeks are the signature symptom of PFAPA syndrome. PFAPA is an acquired autoinflammatory disorder, which recurs in association with at least one sign of aphthous stomatitis, pharyngitis, and cervical lymph node enlargement. The aim of this retrospective case report is to gain an impression of the course of disease during individualized homeopathic treatment in children suffering from PFAPA.

Detailed description

In this retrospective study, the investigators collected the history and symptoms of 13 consecutive PFAPA patients. The investigators also described the individually chosen homeopathic medicinal products (HMPs) used, as well as the course of the disease. Clinical outcome of case reports was assessed using the Modified Naranjo Criteria for Homeopathy-Causal Attribution Inventory. Eight points are taken as the threshold for the possible correlation between homeopathic therapy and improvement of symptoms or cure in chronic cases

Interventions

DRUGHomeopathic Globule

Homeopathic globules were administered after careful anamnesis

Sponsors

Michael Frass
Lead SponsorOTHER

Study design

Observational model
OTHER
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
1 Years to 10 Years
Healthy volunteers
No

Inclusion criteria

Children suffering from fever with at least one of the symptooms of PFAPA besides fever

Exclusion criteria

Parents not willing to sign informed consent.

Design outcomes

Primary

MeasureTime frameDescription
Periodic fever flares30 monthsAppearance of periodic fever flares

Countries

Austria

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026