Disseminated Intravascular Coagulation
Conditions
Keywords
Thrombosis, Coagulation, Hemostatic Biomarkers, DIC
Brief summary
The project was undertaking by Qilu Hospital of Shandong University, aiming to evaluate diagnostic performance of hemostatic biomarkers in disseminated intravascular coagulation.
Detailed description
Disseminated intravascular coagulation (DIC) is a life-threatening condition with high mortality, necessitating timely and accurate diagnosis for effective management. However, current diagnostic systems can not recognize DIC at its reversible phase, causing suboptimal treatment outcomes. Consequently, the current diagnostic criteria for DIC lacks earlier laboratory indicators. Therefore, the investigators aimed to assess the diagnostic potential of selected hemostatic biomarkers, including thrombin-antithrombin complex (TAT), soluble thrombomodulin (sTM), tissue plasminogen activator inhibitor complex (tPAI-C), α2-plasmin inhibitor plasmin complex (PIC) and anti-thrombin III (ATIII), in evaluating DIC, allowing for proactive diagnosis before the disease progresses into its irreversible phase.
Interventions
OTHERno intervention
no intervention
Sponsors
Qilu Hospital of Shandong University
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 94 Years
Healthy volunteers
No
Inclusion criteria
* 18 years old, non-perinatal period, a hospitalization length of≥3 days.
Exclusion criteria
* primary hematologic diseases, decompensated liver cirrhosis, chemotherapy history.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| whether DIC occured | From date of detecting hemostatic biomarkers until the date of first ISTH-DIC scores ≥5, assessed up to 7 days. | DIC includes pre-DIC and overt-DIC |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| whether death occurred | From date of admission until the date of death, assessed up to 5 months | Based on the death records in the electronic medical records |
Countries
China
Contacts
Primary ContactMiao Xu
Outcome results
None listed