Anesthesia, Cesarean Section Complications, Subarachnoid Block
Conditions
Brief summary
compare the time of second hypotension after administration of three different doses of ephedrine 5,10,15 mg
Detailed description
In cesarean section, under subarachnoid block the most common complication is hypotension with a reported incidence greater than 80%. Hypotension may occur even after left uterine displacement and preloading with crystalloid. The severity of hypotension depends on the degree of aortocaval compression syndrome, the amount of crystalloid preloading, doses of local anesthetic drugs administered. The most effective treatment of hypotension associated with cesarean section under subarachnoid block is the administration of vasopressor drugs.
Interventions
DRUGEphedrine 5mg
Patients received 5mg bolus dose of ephedrine Intravenous after the first hypotension \[ Base line time or starting point is first hypotension\]
DRUGEphedrine 10mg
Patients received 10mg bolus dose of ephedrine Intravenous after the first hypotension \[ Base line time or starting point is first hypotension\]
DRUGEphedrine 15mg
Patients received 15mg bolus dose of ephedrine Intravenous after the first hypotension \[ Base line time or starting point is first hypotension\]
Sponsors
Aswan University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* American Society of Anesthesiologists 1 and 2 patients * Gestational amenorrhea of \> 32 weeks * Elective cesarean section * Patient willing for spinal anesthesia. * Singleton pregnancy with cephalic presentation. * Baseline systolic blood pressure between 100-140 mmHg and diastolic blood pressure between 70-89 mmHg.
Exclusion criteria
* Any contraindication to spinal anesthesia, i.e., local infection at the site of injection * valvular heat diseases * bleeding tendency * any co-morbidity like diabetes mellitus * liver cirrhosis * renal failure * any obstetric complications like placenta previa * pregnancy-induced hypertension or HELLP syndrome * multiple gestations * fetal malformation * coagulopathies * morbid obesity and spine deformity * profound hypotension (total spinal) bradycardia and need atropine and severe bleeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Survival analysis or time until an event occurs | Intraoperatively | The study time is a30 minute and blood pressure is measured automatically non invasive at 3-minute intervals. If systolic blood pressure decreased more than 20% from the baseline(Event) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Starting point or Base line time | Intraoperatively | Starting point or Base line time is a first hypotension |
| Survival time | Intraoperatively | Free of event(No hypotension) at any time after base line |
Countries
Egypt
Outcome results
None listed