Chronic Spontaneous Urticaria
Conditions
Keywords
chronic spontaneous urticaria, adenosine deaminase, immunoglobulin E
Brief summary
adenosine deaminase activity (ADA) has been reported to be elevated in various diseases such as psoriasis, acne and juvenile idiopathic arthritis. There is no previous studies that assessed ADA in chronic spontaneous urticaria (CSU) .
Interventions
DIAGNOSTIC_TESTAdenosine deaminase serum level
Adenosine deaminase will be measured by enzymatic (clorometric / kinetic) method (Diazyme laboratories, San Diego, California, USA).
DIAGNOSTIC_TESTIgE antibodies serum level
Level of IgE will be measured by electrochemiluminesence immunoassay (ECLIA, automatic cobase immunoassay, Roche Diagnostics GmbH, Mannheim, USA).
Sponsors
Sohag University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* adult patients complaining of CSU and a group of age and sex-matched healthy controls (blood donors).
Exclusion criteria
* Pregnancy and lactation. * Patients with systemic diseases, especially those with autoimmune diseases and infections. * Patients with skin diseases. * Patients on medications such as antibiotics, nonsteroidal anti-inflammatory drugs, angiotensin-converting enzyme inhibitors, anticonvulsants, penicillin, and combined oral contraceptives.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serum level of adenosine deaminase | 3 months | Difference in serum level of adenosine deaminase between CSU group and control group |
| Serum level of IgE | 3 months | Difference in serum level of IgE between CSU group and control group |
Contacts
Primary ContactAhmed M Ahmed, M.B.B.Ch
Backup ContactRamadan Saleh, MD
Outcome results
None listed