Cardiotoxicity, Chemotherapy Effect, Chemotherapy Induced Systolic Dysfunction
Conditions
Brief summary
Early detection and thus rapid therapy of cardiotoxicity related to chemotherapy are essential for restoring cardiovascular function. The complete recovery of the cardiovascular system decreases with time to identify the presence of cardiotoxic damage. The project aims to define new biomarkers for the early detection of cardiotoxicity in patients treated with chemotherapy.
Detailed description
The most effective approach to minimizing the consequences of cardiotoxicity of oncological treatment is its early identification, adjustment of oncological treatment (change of procedure, dose, drugs), and immediate initiation of cardiovascular therapy. However, the current standard for monitoring the cardiovascular system in cancer patients identifies cardiotoxicity only if functional impairment has already occurred, which precludes any chance of effective prevention. The aim of the project is to identify new biomarkers for the early detection of the cardiotoxic effect of chemotherapy in women with breast cancer.
Interventions
DIAGNOSTIC_TESTBlood sampling
Blood sample collection for mRNA determination
DIAGNOSTIC_TESTEchocardiography
Echocardiography for detection of ventricular dysfunction
DIAGNOSTIC_TESTCardio MRI
MRI for early detection of myocardial impairment caused by chemotherapy
DIAGNOSTIC_TEST24-hours monitoring of ECG
Diagnostic test for detection of arrhythmias as a consequence of cardiotoxicity
DIAGNOSTIC_TEST24 hours monitoring of BP
Diagnostic test for detection of hypertension as a consequence of cardiotoxicity
Sponsors
BioVendor LM
Oncology Center Medicon
Cardiology Prague
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Breast cancer * Chemotherapy with a known cardiotoxic side effect
Exclusion criteria
* Known cardiovascular disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Early detection of the cardiotoxic effect of chemotherapy using new biomarkers | one year follow-up. | Echocardiography and MRI detection of cardiotoxic effect of chemotherapy - dysfunction of left ventricle, arrythmias, hypertension |
Countries
Czechia
Contacts
Primary ContactRobert Petr, MD.
Outcome results
None listed