Digit Tip Wound, Split Skin Donor Site
Conditions
Keywords
Digit Tip, Split Skin Donor Site, Transcriptome
Brief summary
Regrowth of amputated fingertips presents a unique regenerative healing process in mammals, with subcutaneous volume regrowth, restoration of the dactylogram, and suppression of scar formation. In addition, wound healing from split-thickness donor sites shows almost scar-free healing. Transcriptome analysis is necessary to better understand the specific healing mechanisms of these two wound entities. Since no data are available to date, this study aims to fill the gap.
Detailed description
Regrowth of amputated fingertips presents a unique regenerative healing process in mammals, with subcutaneous volume regrowth, restoration of the dactylogram, and suppression of scar formation. In addition, wound healing from split-thickness donor sites shows almost scar-free healing. Transcriptome analysis is necessary to better understand the specific healing mechanisms of these two wound entities. Since no data are available to date, this study aims to fill the gap.
Interventions
OTHERDigit Tip Wound
Digit Tip Wound Exudate Sample Collected while Dressing Change
OTHERSplit Skin Donor Site Wound
Split Skin Donor Site Wound Exudate Sample while Dressing Change
Sponsors
University Hospital Schleswig-Holstein
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
1. Digit Tip Wound: Wound Exudate from healthy patients: Consent-capable patients ≥18 years of age with clean Digit Tip Wound 2. Split Skin Donor Site Wound: Wound Exudate from healthy patients: Consent-capable patients ≥18 years of age with clean Split Skin Donor Site Wound
Exclusion criteria
* Inflammation * Borderline * Infectious Disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Differences in RNA-Expression pattern | 5 Weeks | Differences in RNA-Expression pattern between Digit Tip Wound and Split Skin Donor Site Wound |
Countries
Germany
Outcome results
None listed