Antibiotic-associated Diarrhea, Fecal Microbiota Transplantation
Conditions
Brief summary
Antibiotic-associated diarrhea (AAD) refers to the occurrence of other unexplained diarrhea symptoms after the use of antibiotics, often combined with abdominal pain, bloating and bloody stool. Fecal Microbiota Transplantation (FMT) is a therapeutic method to transplant the microbiota from the feces of healthy people into the intestinal tract of patients. To explore the overall efficacy and safety of FMT in the treatment of AAD.
Interventions
PROCEDUREFecal Microbiota Transplantation
Fecal Microbiota Transplantation (FMT) is a therapeutic method to transplant the microbiota from the feces of healthy people into the intestinal tract of patients. This treatment aims to improve a range of diseases associated with the gut microbiota by restoring the balance of the gut microbiota.
Sponsors
Shanghai 10th People's Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to 78 Years
Healthy volunteers
No
Inclusion criteria
* occurrence of antibiotic-associated diarrhoea; no response to standard therapy; agree to receive FMT and sign informed consent; willingness to provide stool samples.
Exclusion criteria
* non-antibiotic-associated diarrhea; did not accept FMT or did not sign informed consent; unwillingness to provide stool samples.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in defecation frequency after FMT. | Baseline and three months after treatment |
| Changes in gut microbiota after FMT. | Baseline and three months after treatment. |
Countries
China
Outcome results
None listed