Laparoscopic Cholecystectomy, Postoperative Nausea and Vomiting
Conditions
Brief summary
Nausea and vomiting are some of the most common complaints of patients after any anesthesia, which is often associated with postop-erative pain. The double-blind clinical trial study aimed to compare the prophylactic effect of dexamethasone and dexmedetomidine and their combination in reducing postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy.
Interventions
DRUGDexmedetomidine
Intraperitoneal route
DRUGCombination of dexamethasone + dexmedetomidine
Intraperitoneal route
DRUGnormal Saline
Intraperitoneal route
DRUGDexamethasone
Intraperitoneal route
Sponsors
Benha University
Al-Azhar University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Patients aged from 20 - 50 years * ASA I OR II * undergo laparoscopic cholecystectomy
Exclusion criteria
* Patients with history of psychotic illnesses, * Parkinson's disease * motion disorder * Smoker * or history of chemotherapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The number of patients suffered from postoperative nausea and vomiting will be recorded in each group. | 24 hours postoperative |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| antiemetic consumption | 24 hours postoperatively | frequency of antiemetic consumption will be determined |
Countries
Egypt
Outcome results
None listed