Diabetes Mellitus, Type 2, Diastolic Dysfunction, Obesity, Abdominal
Conditions
Brief summary
In type 2 diabetes mellitus (T2DM) and obese patients the adipose tissue could over-express cytokines, sirtuin-1 (SIRT1), and microRNAs (miRs) implied in the regulation of left ventricle (LV) diastolic function (LV-DF). Ghrelin could modulate these pathways. Thus, in the current study authors will investigate ghrelin expression in T2DM obese patients after abdominal fat excision, and particularly in those with normalization of LV-DF at 1 year of follow-up.
Interventions
PROCEDUREabdominal plastic intervention
According to international guidelines, authors will remove the superficial abdominal fat from the patients enrolled in the study.
Sponsors
University of Campania Luigi Vanvitelli
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Clinical diagnosis of T2DM obese patients; * T2DM obese patients under anti-diabetic full medical therapy and glycemic control.
Exclusion criteria
* clinical diagnosis of type 1 diabetes; * T2DM patients in poor glycemic control (HbA1c values of \>7%); * chronic neurological disorders; * heart failure and coronary heart disease or depression of left ventricular ejection fraction (LVEF \<55%); * severe anemia; * thyroid dysfunction; * kidney failure; * uncontrolled blood pressure (blood pressure \> 140/90 mmHg on two occasions 2 weeks apart); * inflammatory chronic disease; * neoplastic disease.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| normalization of LV diastolic dysfunction | 12 months | At 1 year of follow-up authors evaluated the patients (those with first and second degree of LV diastolic dysfunction) that will experience the normalization of LV diastolic function. |
Countries
Italy
Outcome results
None listed