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Surgical Treatment of Stage T3 Squamous Cell Carcinomas of the Scalp

Surgical Treatment of Stage T3 Squamous Cell Carcinomas of the Scalp

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05987579
Enrollment
104
Registered
2023-08-14
Start date
2021-05-03
Completion date
2025-12-01
Last updated
2025-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer Head Neck, Squamous Cell Carcinoma, Surgery

Brief summary

This study examines tumor- en surgical characteristics of stage T3 cutaneous squamous cell carcinomas on the scalp, diagnosed between 2010 and 2018. Histological data and patient- and tumor characteristics were collected.

Detailed description

Cutaneous squamous cell carcinoma is the second most common type of non-melanoma skin cancer, following basal cell carcinoma. Following the American Joint Committee on Cancer Tumour, Node and Metastasis (TNM) Classification of Malignant Tumors staging system (TNM8), T3 cutaneous squamous cell carcinomas comprise an interesting group, especially on the scalp, because of the thin subcutaneous fat layer. According to the TNM8 criteria, T3 include all cutaneous squamous cel carcinomas with greatest tumor dimension ≥4cm, tumors with minimal bone erosion or perineural growth (defined as involvement of the nerve sheath of a nerve lying deeper than the dermis or measuring 0.1mm or larger in caliber or showing clinical or radiographic involvement of nerves without invasion of the skull base) or with deep invasion. Deep invasion is defined as invasion deeper than the subcutaneous fat or a tumor thickness \>6mm. The scalp has a natural anatomical and oncological barrier for extension in depth known as the epicranial aponeurosis, also called the galea aponeurotica. This retrospective study, examines the tumor- en surgical characteristics of these stage T3 cutaneous squamous cell carcinomas on the scalp.

Interventions

None listed

Sponsors

Maastricht University Medical Center
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* stage T3 cutaneous squamous cell carcinoma of the scalp (histologically proven) * surgical treatment or radiotherapy treatment

Exclusion criteria

* metastasis by diagnosis * stage T1/T2/T4

Design outcomes

Primary

MeasureTime frameDescription
Surgical characteristicsBetween 2010-2017Choice of treatment, complications, reconstruction types
Tumor characteristicsBetween 2010-2017Histological data on invasion depth, tumor differentiation
Patients characteristicsBetween 2010-2017Risk factors, comorbidities

Countries

Netherlands

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026