Hypertension
Conditions
Brief summary
The purpose of this study us to investigate the effects of mistimed eating on blood pressure, kidney function and vascular function.
Detailed description
Despite advancements in pharmacologic antihypertensives, hypertension currently affects 1 in 3 Americans and accounts for more than $50 billion of health care spending. Importantly, hypertension is the leading cause of cardiovascular (CVD) and kidney diseases (CKD). As a result, the AHA/ACC lowered the diagnostic criteria for hypertension to encourage earlier preventative lifestyle intervention. There is a critical need to identify and implement novel lifestyle interventions in individuals with early-stage hypertension to prevent the subsequent development of CVD and CKD. Chronotherapy that aligns behavioral cues (such as time of eating) with the body's internal biological clocks, has gained much attention as a potential strategy to prevent and manage hypertension, however, the underlying mechanisms are not yet fully understood. The purpose of this study is to investigate the effects of mistimed eating on blood pressure, kidney function and vascular function.
Interventions
OTHERMorning meal challenge
A Western-style diet meal which will be individualized for caloric consumption by estimated total daily energy expenditure eaten after 1 hour of waking up in the morning
OTHEREvening meal challenge
A Western-style diet meal which will be individualized for caloric consumption by estimated total daily energy expenditure eaten within 1 hour of going to bed
Sponsors
Virginia Commonwealth University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Men and Women aged 18-45 years * Elevated (SBP 120-129; DBP \<80 mmHg) or stage 1 hypertension (SBP 130-139; DBP 80-89 mmHg)
Exclusion criteria
* History of chronic disease (CV, lung, cancer, renal, sleep apnea, diabetes, autoimmune) * Anti-hypertensive medication use * Currently pregnant or lactating * Current shift worker * Travel \>3 time zones four weeks before the start of the study or during the study * Insomnia * Practiced intermittent fasting in past six months * Current nicotine use * Current hormone replacement therapy * Current melatonin use * Current use of antioxidants and unwilling to stop taking them for the duration of the study * Unable to provide informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Urinary sodium excretion and markers of kidney injury | 24 hours | Day and nocturnal urinary sodium, NGAL and KIM-1 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 24hr ambulatory blood pressure | 24 Hours | Day and nocturnal ambulatory blood pressure |
| Macrovascular function | At baseline and after each 24hour experimental arm | Brachial artery endothelial function assessed by flow mediated dilation |
| Microvascular function | At baseline and after each 24hour experimental arm | Skin blood flow response to local heating measured by laser doppler flowmetry |
Countries
United States
Outcome results
None listed