Post Stroke Epilepsy
Conditions
Keywords
post-stroke epilepsy, idebenone
Brief summary
According to the random number table, all patients were divided into short-term treatment group, long-term treatment group and non-intervention stroke control group according to the proportion of (1:1:1) epilepsy disease modifier idebenone. Patients in the short-term treatment group will take idebenone for a total course of 14 days (acute period) after stroke, and patients in the long-term treatment group will take idebenone for a total course of 3 months after stroke.
Interventions
DRUGidebenone 30 mg for 3 months
The patient will be treated with oral idebenone 30 mg three times a day after stroke for a total course of 3 months.
DRUGidebenone 30 mg for 14 days
The patient received oral idebenone 30 mg three times a day after stroke for a total course of 14 days (acute phase).
Sponsors
Xiangya Hospital of Central South University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients admitted to hospital within 24 hours of stroke symptoms and diagnosed with stroke (including cerebral infarction, cerebral hemorrhage, subarachnoid hemorrhage, intracranial venous sinus thrombosis, etc.) after relevant examinations; * Able to cooperate with the inspection; * Sign the informed consent form.
Exclusion criteria
* History of epilepsy before stroke; * A history of serious comorbidities that may lead to seizures (including malignant tumors, specific autoimmune diseases, severe electrolyte abnormalities, end-stage renal disease, and severe head trauma); * Secondary stroke caused by head trauma or surgery; * Other patients that the researchers think need to be excluded.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The proportion of patients with epilepsy after stroke | At the time of enrollment | Count the number of people with post-stroke epilepsy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| National Institutes of Health Stroke Scale (NIHSS) | At the time of enrollment | The minimum value is 0, the maximum value is 24, the higher score indicates the more severe neurological impairment in stroke patients |
| Hamilton Anxiety Scale (HAMA) | At the time of enrollment | The minimum value is 0, the maximum value is 56, the higher score indicates a great likelihood of anxiety |
| Hamilton Depression Scale (HAMD) | At the time of enrollment | The minimum value is 0, the maximum value is 77, the higher score indicates a great likelihood of depression |
| Pittsburgh sleep quality index (PSQI) | At the time of enrollment | The minimum value is 0, the maximum value is 21, the higher score indicates poorer sleep quality |
| Stroke specific quality of life scale (SS-QOL) | At the time of enrollment | The minimum value is 38, the maximum value is 190, the higher score indicates better quality of life |
Countries
China
Contacts
Primary ContactLi Feng, PhD
Outcome results
None listed