Polycystic Ovary Syndrome
Conditions
Brief summary
Obese women with polycystic ovarian syndrome aged between 25 and 35 years old will be divided into three groups. For three months, group (A) will receive laser puncture (3 sessions per week), along with a metformin supplementation, group (B) will receive ultraviolet radiation (3 sessions per week), along with a metformin supplementation, while group (C) will receive only metformin supplementation. The follicular size will be measured using ultrasound, while, female sex hormones, and serum 25-hydroxyvitamin D levels will bel evaluated using blood analysis
Detailed description
Obese women with polycystic ovarian syndrome aged between 25 and 35 years old will be divided into three groups. For three months, group (A) will receive laser puncture (3 sessions per week), along with a metformin supplementation, group (B) will receive ultraviolet radiation (3 sessions per week), along with a metformin supplementation, while group (C) will receive only metformin supplementation. The follicular size will be measured using ultrasound, while, female sex hormones, and serum 25-hydroxyvitamin D levels will bel evaluated using blood analysis
Interventions
DEVICEaser puncture
laser puncture (3 sessions per week)
DEVICEultraviolet radiatio
ultraviolet radiation (3 sessions per week)
DRUGMetformin
for 3 months
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* Obese nulli gravid PCOS women * BMI 30-40 kg/m2
Exclusion criteria
* hyperprolactinemia * BMI \> 40 kg/m2 Endocrinological disorders such as thyroid disease, Cushing's syndrome, Coagulopathy * Recent use of oral contraceptive pills * Recent use of any photosensitizing medications, such as aspirin, tetracycline, chlorothiazide, or psoralen suspicious of neoplasms
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| LH/FSH ratio | 1 month after treatment | LH/FSH ratio measured in venous sample on day 3 of the menstrual cycle |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Serum 25-hydroxyvitamin D concentration | 1 month after treatment | 25-hydroxyvitamin D measured in venous sample |
Countries
Egypt
Contacts
Primary ContactAhmed M Maged
Backup ContactWafaa Kamal
Outcome results
None listed