Complex Regional Pain Syndromes
Conditions
Brief summary
This observational study aims to understand phenotype-specific molecular signatures in patients with complex regional pain syndrome (CRPS).
Detailed description
Participants who meet the diagnostic criteria for CRPS, aged 19\ 80 years, and agree to participate in this study will undergo a 4mm-sized skin punch biopsy in the involved limb, as well as the contralateral side (internal control). Spatial transcriptomics will be used to identify immune cell signatures and differentially regulated genes (DEGs) in the epidermis, vasculature, sweat gland, and nerve plexus of the involved ipsilateral (vs contralateral) side of the patient's skin.
Interventions
None listed
Sponsors
Hanyang University
Seoul National University
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
19 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Meets the Budapest diagnostic criteria * Consents to participation in this study * Aged between 19 and 80 years old * Symptoms and/or signs of sensory, vasomotor, and sudomotor changes
Exclusion criteria
* Who do not agree to participate in this study * Who has contraindications for skin punch biopsy (e.g. thrombocytopenia, taking anticoagulant drugs)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Numerical Rating Scale (NRS) | At the time of biopsy | Intensity of pain (now, weekly avarege, weekly maximum) |
| Thermography | At the time of diagnosis | Thermography of the involved limb |
| Quantitative Sensory Testing (QST) | At the time of diagnosis | Vibration Detection Threshold (VDT), Cold Detection Threshold (CDT) |
Countries
South Korea
Contacts
Primary ContactJee Youn Moon, MD, PhD
Backup ContactJeongsoo Kim, MD
Outcome results
None listed