Bronchopulmonary Dysplasia
Conditions
Keywords
Respiratory oscillometry, Respiratory system reactance, Lung mechanics, Infant lung function testing
Brief summary
The goal of this observational study is to learn about the correlation between respiratory system reactance, as assessed by respiratory oscillometry, and respiratory outcomes in preterm infants born before 32 weeks of gestation. The main question it aims to answer is if the reactance z-score at 7 postnatal days adds to relevant clinical factors in the prediction of bronchopulmonary dysplasia. Participants will receive respiratory oscillometry measurements at 7 ± 2 postnatal days.
Interventions
DIAGNOSTIC_TESTRespiratory Oscillometry
Measurement of respiratory system reactance by respiratory oscillometry
Sponsors
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
University Children's Hospital Basel
Uppsala University Hospital
Medical University of Vienna
Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC)
Fondazione IRCCS San Gerardo dei Tintori
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
5 Days to 9 Days
Healthy volunteers
No
Inclusion criteria
* born before 32 weeks post-menstrual age
Exclusion criteria
* congenital abnormalities * Inherited disorders of metabolism
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Respiratory system reactance (Xrs) at the clinical positive end-expiratory pressure | Xrs will be measured at 7 days of life | Xrs will be expressed in z-score using reference equation for very preterm infants |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Respiratory system reactance (Xrs) at the clinical positive end-expiratory pressure and ± 2 cmH2O | Xrs will be measured at 7 days of life | Xrs will be expressed in cmH2O\*S/L |
Other
| Measure | Time frame | Description |
|---|---|---|
| Respiratory support mode | 7 postnatal days | Respiratory support mode will be coded as 0 = no respiratory support, 1 = nasal high flow therapy, 2 = nasal CPAP or nasal IPPV, 3 = invasive mechanical ventilation |
| Fraction of inspired oxygen | 7 days of life | — |
Countries
Austria, Italy, Netherlands, Sweden, Switzerland
Contacts
Primary ContactCamilla Rigotti, PhD
Backup ContactEmanuela Zannin, PhD
Outcome results
None listed