Effect of Collagen Versus PRF on BMA Osteogenic Potential

Evaluation of Collagen Versus Platelet Rich Fibrin Membrane on the Osteogenic Potential of Bone Marrow Aspirate Concentrate (BMAC) for Lateral Sinus Floor Augmentation : A Randomized Clinical Trial.

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05985317

Enrollment

Registered

2023-08-14

Start date

2023-01-25

Completion date

2023-08-30

Last updated

2023-08-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bone Loss, Alveolar

Brief summary

Utilization of collagen vs PRF membrane over the graft following sinus lift procedure and before suturing

Detailed description

Assessment of the effect of membrane overlying bone marrow aspirate concentrate - bovine graft mixture in sinus lift procedure

Interventions

PROCEDURECollagen membrane over BMAC/bovine graft in sinus lift

Collagen membrane to cover BMAC/bovine graft in sinus lift and evaluation of its effect on osteogenic potential of BMAC in sinus lift procedure

PROCEDUREPRF membrane over BMAC/bovine graft in sinus lift

PRF membrane to cover BMAC/bovine graft in sinus lift and evaluation of its effect on osteogenic potential of BMAC in sinus lift procedure

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients who has as deficient as 4 mm vertical bone height in posterior maxilla that need bone augmentation before delayed implant placement. * Highly motivated patients * Age more than 18 years

Exclusion criteria

* Patients suffering from any systemic disease or those under any medication that may interfere with normal bone healing. * Patients suffering from any sinus pathosis. * Patients with conditions that could potentially compromise Bone Marrow ( BM)quality, including history of hematologic malignancy, current chemotherapy, BM suppressive and anti-platelet medications, previous BM Aspiration, or acute illness. * Heavy smoker (\> 20 cigarettes daily)

Design outcomes

Primary

Measure	Time frame	Description
Radiographic Bone density assessment	4 months ( immediate - 4 months postoperative)	Bone density measurements on Cone beam CT/CBCT immediate and 4 months radiographic density measurements in haunsfield units, immediate and 4 months postoperative

Secondary

Measure	Time frame	Description
Radiographic Bone height assessment	4 months ( immediate - 4 months postoperative)	Assessment of bone hight on CBCT, mmediate and at 4 months postoperative

Countries

Egypt

Contacts

Primary ContactWalaa Kadry

walaakadry@dentistry.cu.edu.eg+201061527359

Backup ContactAbmed Amin

ahmamin2001.aa@gmail.com+201061527358

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026