Acne Scars - Atrophic
Conditions
Brief summary
Assessment of nano fat grafting combined with carbon dioxide laser resurfacing versus nano fat grafting alone in treating facial atrophic acne scars
Detailed description
Acne scars is a world wide problem .though lots of treatment exists still mo gold standard for treatment of acne scars in this study. Assessment of nano fat grafting combined with carbon dioxide laser resurfacing versus nano fat grafting alone in treating facial atrophic acne scars
Interventions
PROCEDUREFat grafting
Nano fat grafting followed by fractional carbon dioxide laser resurfacing
Sponsors
Assiut University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
16 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* patients older than 18 years who attend the Outpatient Clinics of Dermatology and Plastic Surgery Departments, Assiut University Hospital, with moderate to severe atrophic facial acne scars on both cheeks, as assessed using the Goodman and Baron Qualitative scar grading system (12), will be enrolled in the study.
Exclusion criteria
* include: pregnancy or lactation; active acne, history of deep chemical peeling or filler injection in the previous 6 months, history of keloid or hypertrophic scar formation; use of isotretinoin in the previous 6 months; active infection in the treatment area; bleeding tendencies; history of herpes simplex or herpes zoster infection on the face; and patients with unrealistic expectations.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical assessment of acne scar severity | up to 24 weeks | as assessed using the Goodman and Baron Qualitative scar grading system before and after treatment on both sides of face, to determine the number of patients achieving two grades improvement vs one grade or no improvement |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Physician global assessment | up to 24 weeks | two blinded observers will compare the before and after photographs separately on each facial side and will evaluate the improvement on a quartile grading scale as: poor,\<25% improvement; fair, 25%-50% improvement; good, 51%-75% improvement; and excellent, \>75% improvement. |
| percent of reduction in scar count | up to 24 weeks | count of the total and different types of acne scars was performed, before and after treatment on both sides of the face, and the percent of reduction was calculated |
| Patient satisfaction | 1 year | Patients will rate their overall satisfaction on a quartile grading system: 0, unsatisfied; 1, slightly satisfied; 2, satisfied; and 3, very satisfied |
| Adverse events | 1 year | erythema, edema, crusting, pigmentary changes, ecchymosis, and scarring, will be recorded |
Countries
Egypt
Contacts
Primary Contactmohammed H Abdelhafez, MBBS
Backup Contactsara M Awad, MD
Outcome results
None listed