Esophageal Squamous Cell Carcinoma
Conditions
Keywords
esophageal squamous cell carcinoma, immunotherapy, chemotherapy, surgery, adjuvant therapy
Brief summary
Esophageal cancer is one of the most common malignancies in China, and esophageal squamous cell carcinoma (ESCC) is the predominant histological type. Surgical resection is still a standard therapeutic approach for patients with resectable ESCC, but the prognosis is still disappointing. Although neoadjuvant chemoradiotherapy plus surgery is currently recommended for patients with locally advanced ESCC, it is still an infrequently used procedure in China. The efficacy of adjuvant therapy on ESCC is still controversial. Recently, the CheckMate 577 trial showed that adjuvant nivolumab therapy could improve DFS for patients with residual disease after neoadjuvant chemoradiotherapy plus surgery. However, no optimal postoperative adjuvant therapy was recommended for patients with ESCC received upfront surgery. We designed a prospective randomized controlled tial to study whether immunotherapy could be used with chemotherapy after surgery to improve overall survival in these patients. The primary endpoint of the study is disease free survival, with secondary endpoints of overall survival, safety and toxicity, and quality of life.
Interventions
DRUGTislelizumab
Adjuvant Chemotherapy （nab-paclitaxel 260mg/m2 d1 plus Cisplatin 75mg/m2 d1 or 25mg/m2 d1-3) in combination with Tislelizumab (200 mg Q3W)
Sponsors
Affiliated Cancer Hospital of Shantou University Medical College
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
1. Aged between 18 and 70 years 2. Untreated before surgery (e.g. radiotherapy, chemotherapy, target therapy and immunotherapy) 3. Histologically documented squamous cell carcinoma of the thoracic esophagus with positive lymph nodes （T1-3N1-3M0） 4. undergoing radical esophagectomy 5. ECOG (Eastern Cooperative Oncology Group) : 0-1 6. No recurrent disease before adjuvant therapy 7. Normal hemodynamic indices before the recruitment 8. Able to understand this study and have signed informed consent
Exclusion criteria
1. previous or concurrent malignancy 2. Interstitial lung disease 3. Requiring systemic treatment with either corticosteroids or other immunosuppressive medications 4. Known or suspected allergy to chemotherapeutic drugs or Tislelizumab 5. Active autoimmune disease 6. Active hepatitis 7. Those whom the investigator considered unsuitable for inclusion
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| disease-free survival rate | 1 years after surgery | disease free survival after surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Rate of adverse events | within 6 months | Rate of adverse events according to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI- CTCAE v5.0) |
Countries
China
Outcome results
None listed