Breathlessness, Dyspnea, Exercise, Lactic Acidosis, Muscle, Recovery
Conditions
Brief summary
The study will evaluate the impact of high velocity therapy (HVT) on reduction of work of breathing (as implied by breath frequency) and enhanced blood lactate decline during recovery from a Wingate-type Exercise test. The study will include four study segments, corresponding to four different therapy settings.
Detailed description
HVT has been found to be a useful clinical tool for treatment of Type 1 and Type 2 respiratory failure (including hypercapnic respiratory failure), acute decompensated heart failure, and COVID respiratory complications. The overall objective of this prospective, pilot study is to evaluate whether HVT might enhance the decline of blood lactate concentrations following a high intensity exercise bout, in healthy volunteers. The hypothesis is that HVT, regardless of the oxygen concentration (i.e., FiO2), will reduce the work of breathing and increase the lactate clearance rate during exercise and recovery intervals. This pilot study could ignite further research providing HVT applications to high performing athletics and patients in an acute care setting requiring physical rehabilitation.
Interventions
DEVICEHigh Velocity Therapy
FiO2=100% with Flow=5LPM FiO2=21% with Flow=25-35LPM FiO2=100% with Flow=25-35LPM FiO2=21% with Flow=5LPM
Sponsors
Auburn University
Vapotherm, Inc.
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* Adults18-30 years old, in a general state of good health, of either sex * No known contraindication to performing a maximal exercise test, i.e., Wingate-type Anaerobic exercise test * Participants must consider themselves able to perform regular moderate or regular strenuous exercise. * ° Regular moderate exercise includes less than 30 minutes every day or 30 minutes every other day, of some form of deliberate exercise, that does not include walking. * ° Regular strenuous exercise is 30+ minutes per day, of some form of deliberate exercise, that does not include walking.
Exclusion criteria
* Not considered a 'high-performance athlete' * Known active cardiovascular, metabolic, liver, or renal disease * Orthopedic limitations to exercise * Pregnancy * Use of beta-blockers or beta-agonist asthma medications * Exercise induced asthma * Any other health-related issue that would involve the participant's fitness capability * Inability to complete all of the study procedures
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood Lactate Change | At rest (TR) and during recovery from the Wingate test at minute 2 (T2) minute 4 (T4), minute 6 (T6), minute 8 (T8), minute 10 (T10) minute 15 (T15), minute 20 (T20), minute 25 (T25), minute 30 (T30) minute 40 (T40), minute 50 (T50) minute 60 (T60). | The change in blood lactate starting from the exercise test throughout the recovery period |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Heart Rate Change | Prior to the Wingate test (TR) and after 2min (T2), 4min (T4), 6min (T6), 8min (T8), 10min (T10), 15min (T15), 20min (T20), 25min (T25), 30min (T30), 40min (T40), 50 min (T50), and 60min (T60) into recovery. | The change in heart rate starting from the exercise test throughout the recovery period |
| SpO2 Change | Prior to the Wingate test (TR) and after at, 2min (T2), 4min (T4), 6min (T6), 8min (T8), 10min (T10), 15min (T15), 20min (T20), 25min (T25), 30min (T30), 40min (T40), 50 min (T50), and 60min (T60) into recovery. | The change in SpO2 starting from the exercise test throughout the recovery period. |
| Respiratory Rate Change | Prior to the Wingate test (TR) and after at 1min (T1), 2min (T2), 4min (T4), 6min (T6), 8min (T8), 10min (T10), 15min (T15), 20min (T20), 25min (T25), 30min (T30), 40min (T40), 50 min (T50), and 60min (T60) into recovery. | The change in respiratory rate starting from the exercise test throughout the recovery period |
| Diastolic Blood Pressure Change | Prior to the Wingate test (TR) and after at, 5min (T5) 10min (T10), 15min (T15), 20min (T20), 25min (T25), 30min (T30), 40min (T40), 50 min (T50), and 60min (T60) into recovery. | The change in diastolic blood pressure change starting from the exercise test throughout the recovery period. |
| Perceived Level of Exertion Change | Immediately after the Wingate test (T0) and after at, 2min (T2), 4min (T4), 6min (T6), 8min (T8), 10min (T10), 15min (T15), 20min (T20), 25min (T25), 30min (T30), 40min (T40), 50 min (T50), and 60min (T60) into recovery. | The change in the subjects perceived level of exertion starting from after the exercise test throughout the recovery period. The scale will be 0-10; a lower score is a lower level of exhaustion, a higher score is a higher level of exhaustion. |
| Systolic Blood Pressure Change | Prior to the Wingate test (TR) and after at, 5min (T5) 10min (T10), 15min (T15), 20min (T20), 25min (T25), 30min (T30), 40min (T40), 50 min (T50), and 60min (T60) into recovery. | The change in systolic blood pressure starting from the exercise test throughout the recovery period. |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| All Participants Subject will receive High Velocity Therapy; four different flow settings and FIO2 for a total of four groups.
FiO2=100% with Flow=5LPM FiO2=21% with Flow=25-30LPM FiO2=100% with Flow=25-30LPM FiO2=21% with Flow=5LPM | 15 |
| Total | 15 |
Baseline characteristics
| Characteristic | All Participants | — |
|---|---|---|
| Age, Categorical <=18 years | 0 Participants | — |
| Age, Categorical >=65 years | 0 Participants | — |
| Age, Categorical Between 18 and 65 years | 15 Participants | — |
| Race and Ethnicity Not Collected | — | — Participants |
| Sex: Female, Male Female | 7 Participants | — |
| Sex: Female, Male Male | 8 Participants | — |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | 0 / 15 |
| other Total, other adverse events | 0 / 15 |
| serious Total, serious adverse events | 0 / 15 |
Outcome results
Primary
Blood Lactate Change
The change in blood lactate starting from the exercise test throughout the recovery period
Time frame: At rest (TR) and during recovery from the Wingate test at minute 2 (T2) minute 4 (T4), minute 6 (T6), minute 8 (T8), minute 10 (T10) minute 15 (T15), minute 20 (T20), minute 25 (T25), minute 30 (T30) minute 40 (T40), minute 50 (T50) minute 60 (T60).
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| FiO2=21% With Flow=5LPM | Blood Lactate Change | T6 | 11.60 mmol/L | Standard Deviation 1.96 |
| FiO2=21% With Flow=5LPM | Blood Lactate Change | T4 | 11.05 mmol/L | Standard Deviation 2.16 |
| FiO2=21% With Flow=5LPM | Blood Lactate Change | T2 | 9.85 mmol/L | Standard Deviation 2.24 |
| FiO2=21% With Flow=5LPM | Blood Lactate Change | TR | 1.19 mmol/L | Standard Deviation 0.49 |
| FiO2=21% With Flow=5LPM | Blood Lactate Change | T8 | 11.30 mmol/L | Standard Deviation 2.22 |
| FiO2=21% With Flow=5LPM | Blood Lactate Change | T50 | 3.39 mmol/L | Standard Deviation 0.95 |
| FiO2=21% With Flow=5LPM | Blood Lactate Change | T40 | 4.49 mmol/L | Standard Deviation 1.29 |
| FiO2=21% With Flow=5LPM | Blood Lactate Change | T25 | 7.39 mmol/L | Standard Deviation 2.14 |
| FiO2=21% With Flow=5LPM | Blood Lactate Change | T20 | 8.73 mmol/L | Standard Deviation 2.24 |
| FiO2=21% With Flow=5LPM | Blood Lactate Change | T60 | 2.26 mmol/L | Standard Deviation 0.73 |
| FiO2=21% With Flow=5LPM | Blood Lactate Change | T30 | 6.22 mmol/L | Standard Deviation 1.66 |
| FiO2=21% With Flow=5LPM | Blood Lactate Change | T15 | 10.07 mmol/L | Standard Deviation 2.36 |
| FiO2=21% With Flow=5LPM | Blood Lactate Change | T10 | 11.30 mmol/L | Standard Deviation 2.33 |
| FiO2=21% With Flow=25-35LPM | Blood Lactate Change | T4 | 10.75 mmol/L | Standard Deviation 2.24 |
| FiO2=21% With Flow=25-35LPM | Blood Lactate Change | T40 | 4.31 mmol/L | Standard Deviation 1.59 |
| FiO2=21% With Flow=25-35LPM | Blood Lactate Change | T50 | 3.27 mmol/L | Standard Deviation 1.1 |
| FiO2=21% With Flow=25-35LPM | Blood Lactate Change | T60 | 2.61 mmol/L | Standard Deviation 0.9 |
| FiO2=21% With Flow=25-35LPM | Blood Lactate Change | T6 | 11.33 mmol/L | Standard Deviation 2.03 |
| FiO2=21% With Flow=25-35LPM | Blood Lactate Change | T8 | 11.29 mmol/L | Standard Deviation 2.49 |
| FiO2=21% With Flow=25-35LPM | Blood Lactate Change | T10 | 11.13 mmol/L | Standard Deviation 2.41 |
| FiO2=21% With Flow=25-35LPM | Blood Lactate Change | T2 | 9.63 mmol/L | Standard Deviation 2.32 |
| FiO2=21% With Flow=25-35LPM | Blood Lactate Change | T15 | 9.59 mmol/L | Standard Deviation 2.42 |
| FiO2=21% With Flow=25-35LPM | Blood Lactate Change | T20 | 8.20 mmol/L | Standard Deviation 2.26 |
| FiO2=21% With Flow=25-35LPM | Blood Lactate Change | TR | 1.22 mmol/L | Standard Deviation 0.98 |
| FiO2=21% With Flow=25-35LPM | Blood Lactate Change | T25 | 6.90 mmol/L | Standard Deviation 2.03 |
| FiO2=21% With Flow=25-35LPM | Blood Lactate Change | T30 | 5.84 mmol/L | Standard Deviation 1.91 |
| FiO2=100% With Flow=5LPM | Blood Lactate Change | T40 | 4.07 mmol/L | Standard Deviation 1.23 |
| FiO2=100% With Flow=5LPM | Blood Lactate Change | T15 | 9.43 mmol/L | Standard Deviation 2.01 |
| FiO2=100% With Flow=5LPM | Blood Lactate Change | T2 | 9.55 mmol/L | Standard Deviation 1.48 |
| FiO2=100% With Flow=5LPM | Blood Lactate Change | TR | 1.11 mmol/L | Standard Deviation 0.36 |
| FiO2=100% With Flow=5LPM | Blood Lactate Change | T25 | 6.72 mmol/L | Standard Deviation 1.99 |
| FiO2=100% With Flow=5LPM | Blood Lactate Change | T20 | 8.04 mmol/L | Standard Deviation 2.06 |
| FiO2=100% With Flow=5LPM | Blood Lactate Change | T8 | 11.14 mmol/L | Standard Deviation 1.96 |
| FiO2=100% With Flow=5LPM | Blood Lactate Change | T6 | 10.83 mmol/L | Standard Deviation 1.81 |
| FiO2=100% With Flow=5LPM | Blood Lactate Change | T30 | 5.49 mmol/L | Standard Deviation 1.52 |
| FiO2=100% With Flow=5LPM | Blood Lactate Change | T4 | 10.86 mmol/L | Standard Deviation 1.9 |
| FiO2=100% With Flow=5LPM | Blood Lactate Change | T10 | 10.63 mmol/L | Standard Deviation 2.03 |
| FiO2=100% With Flow=5LPM | Blood Lactate Change | T50 | 2.95 mmol/L | Standard Deviation 0.91 |
| FiO2=100% With Flow=5LPM | Blood Lactate Change | T60 | 2.37 mmol/L | Standard Deviation 0.72 |
| FiO2=100% With Flow=25-35LPM | Blood Lactate Change | T60 | 2.41 mmol/L | Standard Deviation 0.73 |
| FiO2=100% With Flow=25-35LPM | Blood Lactate Change | TR | 1.05 mmol/L | Standard Deviation 0.42 |
| FiO2=100% With Flow=25-35LPM | Blood Lactate Change | T2 | 9.56 mmol/L | Standard Deviation 2.19 |
| FiO2=100% With Flow=25-35LPM | Blood Lactate Change | T4 | 10.61 mmol/L | Standard Deviation 2.19 |
| FiO2=100% With Flow=25-35LPM | Blood Lactate Change | T6 | 10.89 mmol/L | Standard Deviation 2.05 |
| FiO2=100% With Flow=25-35LPM | Blood Lactate Change | T8 | 10.26 mmol/L | Standard Deviation 1.91 |
| FiO2=100% With Flow=25-35LPM | Blood Lactate Change | T10 | 10.22 mmol/L | Standard Deviation 1.92 |
| FiO2=100% With Flow=25-35LPM | Blood Lactate Change | T15 | 9.16 mmol/L | Standard Deviation 2.37 |
| FiO2=100% With Flow=25-35LPM | Blood Lactate Change | T20 | 7.73 mmol/L | Standard Deviation 2.02 |
| FiO2=100% With Flow=25-35LPM | Blood Lactate Change | T25 | 6.53 mmol/L | Standard Deviation 1.91 |
| FiO2=100% With Flow=25-35LPM | Blood Lactate Change | T30 | 5.47 mmol/L | Standard Deviation 1.63 |
| FiO2=100% With Flow=25-35LPM | Blood Lactate Change | T40 | 3.99 mmol/L | Standard Deviation 1.21 |
| FiO2=100% With Flow=25-35LPM | Blood Lactate Change | T50 | 2.96 mmol/L | Standard Deviation 0.94 |
Secondary
Diastolic Blood Pressure Change
The change in diastolic blood pressure change starting from the exercise test throughout the recovery period.
Time frame: Prior to the Wingate test (TR) and after at, 5min (T5) 10min (T10), 15min (T15), 20min (T20), 25min (T25), 30min (T30), 40min (T40), 50 min (T50), and 60min (T60) into recovery.
Population: Subjects that had this data collected for the specified time point.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| FiO2=21% With Flow=5LPM | Diastolic Blood Pressure Change | TR | 75.73 mmHg | Standard Deviation 8.5 |
| FiO2=21% With Flow=5LPM | Diastolic Blood Pressure Change | T5 | 67.20 mmHg | Standard Deviation 8.6 |
| FiO2=21% With Flow=5LPM | Diastolic Blood Pressure Change | T10 | 70.00 mmHg | Standard Deviation 10.99 |
| FiO2=21% With Flow=5LPM | Diastolic Blood Pressure Change | T15 | 71.31 mmHg | Standard Deviation 14.33 |
| FiO2=21% With Flow=5LPM | Diastolic Blood Pressure Change | T20 | 70.47 mmHg | Standard Deviation 6.06 |
| FiO2=21% With Flow=5LPM | Diastolic Blood Pressure Change | T25 | 70.27 mmHg | Standard Deviation 6.6 |
| FiO2=21% With Flow=5LPM | Diastolic Blood Pressure Change | T30 | 70.13 mmHg | Standard Deviation 7.18 |
| FiO2=21% With Flow=5LPM | Diastolic Blood Pressure Change | T40 | 69.27 mmHg | Standard Deviation 9.09 |
| FiO2=21% With Flow=5LPM | Diastolic Blood Pressure Change | T50 | 72.27 mmHg | Standard Deviation 20.09 |
| FiO2=21% With Flow=5LPM | Diastolic Blood Pressure Change | T60 | 69.71 mmHg | Standard Deviation 7.72 |
| FiO2=21% With Flow=25-35LPM | Diastolic Blood Pressure Change | T10 | 70.20 mmHg | Standard Deviation 6.67 |
| FiO2=21% With Flow=25-35LPM | Diastolic Blood Pressure Change | T50 | 71.27 mmHg | Standard Deviation 7.64 |
| FiO2=21% With Flow=25-35LPM | Diastolic Blood Pressure Change | T15 | 70.80 mmHg | Standard Deviation 12.19 |
| FiO2=21% With Flow=25-35LPM | Diastolic Blood Pressure Change | T20 | 72.57 mmHg | Standard Deviation 7.24 |
| FiO2=21% With Flow=25-35LPM | Diastolic Blood Pressure Change | T25 | 74.86 mmHg | Standard Deviation 9.45 |
| FiO2=21% With Flow=25-35LPM | Diastolic Blood Pressure Change | T30 | 72.07 mmHg | Standard Deviation 7.08 |
| FiO2=21% With Flow=25-35LPM | Diastolic Blood Pressure Change | T60 | 71.40 mmHg | Standard Deviation 9.16 |
| FiO2=21% With Flow=25-35LPM | Diastolic Blood Pressure Change | T40 | 76.60 mmHg | Standard Deviation 12.48 |
| FiO2=21% With Flow=25-35LPM | Diastolic Blood Pressure Change | TR | 76.73 mmHg | Standard Deviation 7.86 |
| FiO2=21% With Flow=25-35LPM | Diastolic Blood Pressure Change | T5 | 69.14 mmHg | Standard Deviation 8.96 |
| FiO2=100% With Flow=5LPM | Diastolic Blood Pressure Change | T40 | 72.80 mmHg | Standard Deviation 11.45 |
| FiO2=100% With Flow=5LPM | Diastolic Blood Pressure Change | T30 | 69.93 mmHg | Standard Deviation 4.68 |
| FiO2=100% With Flow=5LPM | Diastolic Blood Pressure Change | T60 | 71.50 mmHg | Standard Deviation 5.23 |
| FiO2=100% With Flow=5LPM | Diastolic Blood Pressure Change | TR | 75.53 mmHg | Standard Deviation 8.56 |
| FiO2=100% With Flow=5LPM | Diastolic Blood Pressure Change | T15 | 74.29 mmHg | Standard Deviation 5.46 |
| FiO2=100% With Flow=5LPM | Diastolic Blood Pressure Change | T25 | 70.53 mmHg | Standard Deviation 6.14 |
| FiO2=100% With Flow=5LPM | Diastolic Blood Pressure Change | T50 | 71.07 mmHg | Standard Deviation 6.61 |
| FiO2=100% With Flow=5LPM | Diastolic Blood Pressure Change | T5 | 68.93 mmHg | Standard Deviation 5.64 |
| FiO2=100% With Flow=5LPM | Diastolic Blood Pressure Change | T20 | 77.67 mmHg | Standard Deviation 20.7 |
| FiO2=100% With Flow=5LPM | Diastolic Blood Pressure Change | T10 | 69.40 mmHg | Standard Deviation 4.55 |
| FiO2=100% With Flow=25-35LPM | Diastolic Blood Pressure Change | T20 | 77.07 mmHg | Standard Deviation 18.85 |
| FiO2=100% With Flow=25-35LPM | Diastolic Blood Pressure Change | T40 | 76.13 mmHg | Standard Deviation 12.86 |
| FiO2=100% With Flow=25-35LPM | Diastolic Blood Pressure Change | T25 | 74.07 mmHg | Standard Deviation 11.15 |
| FiO2=100% With Flow=25-35LPM | Diastolic Blood Pressure Change | T60 | 71.33 mmHg | Standard Deviation 5.75 |
| FiO2=100% With Flow=25-35LPM | Diastolic Blood Pressure Change | T30 | 70.87 mmHg | Standard Deviation 8.84 |
| FiO2=100% With Flow=25-35LPM | Diastolic Blood Pressure Change | T5 | 68.53 mmHg | Standard Deviation 6.72 |
| FiO2=100% With Flow=25-35LPM | Diastolic Blood Pressure Change | T10 | 72.20 mmHg | Standard Deviation 16.4 |
| FiO2=100% With Flow=25-35LPM | Diastolic Blood Pressure Change | T15 | 69.92 mmHg | Standard Deviation 6.63 |
| FiO2=100% With Flow=25-35LPM | Diastolic Blood Pressure Change | TR | 75.00 mmHg | Standard Deviation 9.46 |
| FiO2=100% With Flow=25-35LPM | Diastolic Blood Pressure Change | T50 | 71.73 mmHg | Standard Deviation 7.27 |
Secondary
Heart Rate Change
The change in heart rate starting from the exercise test throughout the recovery period
Time frame: Prior to the Wingate test (TR) and after 2min (T2), 4min (T4), 6min (T6), 8min (T8), 10min (T10), 15min (T15), 20min (T20), 25min (T25), 30min (T30), 40min (T40), 50 min (T50), and 60min (T60) into recovery.
Population: Subjects that had this data collected for the specified time point.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| FiO2=21% With Flow=5LPM | Heart Rate Change | T2 | 121.60 Beats per min | Standard Deviation 10.03 |
| FiO2=21% With Flow=5LPM | Heart Rate Change | T20 | 97.13 Beats per min | Standard Deviation 9.49 |
| FiO2=21% With Flow=5LPM | Heart Rate Change | T30 | 93.40 Beats per min | Standard Deviation 10.18 |
| FiO2=21% With Flow=5LPM | Heart Rate Change | T25 | 96.87 Beats per min | Standard Deviation 11.11 |
| FiO2=21% With Flow=5LPM | Heart Rate Change | TR | 78.7 Beats per min | Standard Deviation 11.87 |
| FiO2=21% With Flow=5LPM | Heart Rate Change | T60 | 89.47 Beats per min | Standard Deviation 8.9 |
| FiO2=21% With Flow=5LPM | Heart Rate Change | T4 | 107.27 Beats per min | Standard Deviation 10.98 |
| FiO2=21% With Flow=5LPM | Heart Rate Change | T50 | 90.73 Beats per min | Standard Deviation 8.25 |
| FiO2=21% With Flow=5LPM | Heart Rate Change | T6 | 103.33 Beats per min | Standard Deviation 8.59 |
| FiO2=21% With Flow=5LPM | Heart Rate Change | T8 | 102.93 Beats per min | Standard Deviation 8.53 |
| FiO2=21% With Flow=5LPM | Heart Rate Change | T10 | 100.73 Beats per min | Standard Deviation 8.83 |
| FiO2=21% With Flow=5LPM | Heart Rate Change | T40 | 93.87 Beats per min | Standard Deviation 11.18 |
| FiO2=21% With Flow=5LPM | Heart Rate Change | T15 | 98.73 Beats per min | Standard Deviation 8.96 |
| FiO2=21% With Flow=25-35LPM | Heart Rate Change | T15 | 101.00 Beats per min | Standard Deviation 7.65 |
| FiO2=21% With Flow=25-35LPM | Heart Rate Change | T30 | 95.93 Beats per min | Standard Deviation 9.91 |
| FiO2=21% With Flow=25-35LPM | Heart Rate Change | T10 | 102.73 Beats per min | Standard Deviation 10.5 |
| FiO2=21% With Flow=25-35LPM | Heart Rate Change | T20 | 98.47 Beats per min | Standard Deviation 8.4 |
| FiO2=21% With Flow=25-35LPM | Heart Rate Change | T2 | 120.53 Beats per min | Standard Deviation 17.22 |
| FiO2=21% With Flow=25-35LPM | Heart Rate Change | T6 | 106.27 Beats per min | Standard Deviation 11.65 |
| FiO2=21% With Flow=25-35LPM | Heart Rate Change | TR | 77.43 Beats per min | Standard Deviation 10.93 |
| FiO2=21% With Flow=25-35LPM | Heart Rate Change | T25 | 96.27 Beats per min | Standard Deviation 10.93 |
| FiO2=21% With Flow=25-35LPM | Heart Rate Change | T8 | 104.67 Beats per min | Standard Deviation 10.76 |
| FiO2=21% With Flow=25-35LPM | Heart Rate Change | T60 | 89.87 Beats per min | Standard Deviation 10.79 |
| FiO2=21% With Flow=25-35LPM | Heart Rate Change | T40 | 90.53 Beats per min | Standard Deviation 8.72 |
| FiO2=21% With Flow=25-35LPM | Heart Rate Change | T4 | 107.93 Beats per min | Standard Deviation 11.97 |
| FiO2=21% With Flow=25-35LPM | Heart Rate Change | T50 | 90.53 Beats per min | Standard Deviation 9.35 |
| FiO2=100% With Flow=5LPM | Heart Rate Change | T4 | 103.27 Beats per min | Standard Deviation 10.4 |
| FiO2=100% With Flow=5LPM | Heart Rate Change | TR | 77.33 Beats per min | Standard Deviation 11.08 |
| FiO2=100% With Flow=5LPM | Heart Rate Change | T2 | 117.13 Beats per min | Standard Deviation 7.64 |
| FiO2=100% With Flow=5LPM | Heart Rate Change | T6 | 100.80 Beats per min | Standard Deviation 10.36 |
| FiO2=100% With Flow=5LPM | Heart Rate Change | T8 | 101.73 Beats per min | Standard Deviation 8.55 |
| FiO2=100% With Flow=5LPM | Heart Rate Change | T10 | 101.80 Beats per min | Standard Deviation 10.18 |
| FiO2=100% With Flow=5LPM | Heart Rate Change | T15 | 97.86 Beats per min | Standard Deviation 7.85 |
| FiO2=100% With Flow=5LPM | Heart Rate Change | T20 | 95.80 Beats per min | Standard Deviation 9.37 |
| FiO2=100% With Flow=5LPM | Heart Rate Change | T25 | 93.20 Beats per min | Standard Deviation 9.26 |
| FiO2=100% With Flow=5LPM | Heart Rate Change | T30 | 94.80 Beats per min | Standard Deviation 9.21 |
| FiO2=100% With Flow=5LPM | Heart Rate Change | T40 | 92.47 Beats per min | Standard Deviation 8.43 |
| FiO2=100% With Flow=5LPM | Heart Rate Change | T50 | 89.00 Beats per min | Standard Deviation 9.89 |
| FiO2=100% With Flow=5LPM | Heart Rate Change | T60 | 85.57 Beats per min | Standard Deviation 9 |
| FiO2=100% With Flow=25-35LPM | Heart Rate Change | T30 | 94.07 Beats per min | Standard Deviation 9.48 |
| FiO2=100% With Flow=25-35LPM | Heart Rate Change | T10 | 99.87 Beats per min | Standard Deviation 8.36 |
| FiO2=100% With Flow=25-35LPM | Heart Rate Change | T8 | 101.20 Beats per min | Standard Deviation 9.12 |
| FiO2=100% With Flow=25-35LPM | Heart Rate Change | TR | 81.13 Beats per min | Standard Deviation 14.94 |
| FiO2=100% With Flow=25-35LPM | Heart Rate Change | T40 | 89.47 Beats per min | Standard Deviation 9.58 |
| FiO2=100% With Flow=25-35LPM | Heart Rate Change | T4 | 105.00 Beats per min | Standard Deviation 10.45 |
| FiO2=100% With Flow=25-35LPM | Heart Rate Change | T6 | 101.20 Beats per min | Standard Deviation 9.95 |
| FiO2=100% With Flow=25-35LPM | Heart Rate Change | T60 | 86.13 Beats per min | Standard Deviation 9.31 |
| FiO2=100% With Flow=25-35LPM | Heart Rate Change | T50 | 90.00 Beats per min | Standard Deviation 12.26 |
| FiO2=100% With Flow=25-35LPM | Heart Rate Change | T25 | 93.33 Beats per min | Standard Deviation 10.44 |
| FiO2=100% With Flow=25-35LPM | Heart Rate Change | T20 | 95.13 Beats per min | Standard Deviation 10.23 |
| FiO2=100% With Flow=25-35LPM | Heart Rate Change | T15 | 97.20 Beats per min | Standard Deviation 10.48 |
| FiO2=100% With Flow=25-35LPM | Heart Rate Change | T2 | 116.93 Beats per min | Standard Deviation 12.14 |
Secondary
Perceived Level of Exertion Change
The change in the subjects perceived level of exertion starting from after the exercise test throughout the recovery period. The scale will be 0-10; a lower score is a lower level of exhaustion, a higher score is a higher level of exhaustion.
Time frame: Immediately after the Wingate test (T0) and after at, 2min (T2), 4min (T4), 6min (T6), 8min (T8), 10min (T10), 15min (T15), 20min (T20), 25min (T25), 30min (T30), 40min (T40), 50 min (T50), and 60min (T60) into recovery.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| FiO2=21% With Flow=5LPM | Perceived Level of Exertion Change | T0 | 8.40 units on a scale (0-10) | Standard Deviation 2.1 |
| FiO2=21% With Flow=5LPM | Perceived Level of Exertion Change | T2 | 7.07 units on a scale (0-10) | Standard Deviation 1.87 |
| FiO2=21% With Flow=5LPM | Perceived Level of Exertion Change | T4 | 5.73 units on a scale (0-10) | Standard Deviation 2.25 |
| FiO2=21% With Flow=5LPM | Perceived Level of Exertion Change | T6 | 4.80 units on a scale (0-10) | Standard Deviation 2.34 |
| FiO2=21% With Flow=5LPM | Perceived Level of Exertion Change | T8 | 4.13 units on a scale (0-10) | Standard Deviation 2.07 |
| FiO2=21% With Flow=5LPM | Perceived Level of Exertion Change | T10 | 3.67 units on a scale (0-10) | Standard Deviation 2.32 |
| FiO2=21% With Flow=5LPM | Perceived Level of Exertion Change | T15 | 2.80 units on a scale (0-10) | Standard Deviation 2.18 |
| FiO2=21% With Flow=5LPM | Perceived Level of Exertion Change | T20 | 2.33 units on a scale (0-10) | Standard Deviation 2.06 |
| FiO2=21% With Flow=5LPM | Perceived Level of Exertion Change | T25 | 2.07 units on a scale (0-10) | Standard Deviation 1.94 |
| FiO2=21% With Flow=5LPM | Perceived Level of Exertion Change | T30 | 1.73 units on a scale (0-10) | Standard Deviation 1.62 |
| FiO2=21% With Flow=5LPM | Perceived Level of Exertion Change | T40 | 1.40 units on a scale (0-10) | Standard Deviation 1.35 |
| FiO2=21% With Flow=5LPM | Perceived Level of Exertion Change | T50 | .93 units on a scale (0-10) | Standard Deviation 0.96 |
| FiO2=21% With Flow=5LPM | Perceived Level of Exertion Change | T60 | .73 units on a scale (0-10) | Standard Deviation 0.8 |
| FiO2=21% With Flow=25-35LPM | Perceived Level of Exertion Change | T6 | 4.93 units on a scale (0-10) | Standard Deviation 2.71 |
| FiO2=21% With Flow=25-35LPM | Perceived Level of Exertion Change | T60 | .60 units on a scale (0-10) | Standard Deviation 0.74 |
| FiO2=21% With Flow=25-35LPM | Perceived Level of Exertion Change | T40 | 1.27 units on a scale (0-10) | Standard Deviation 1.49 |
| FiO2=21% With Flow=25-35LPM | Perceived Level of Exertion Change | T20 | 2.27 units on a scale (0-10) | Standard Deviation 2.12 |
| FiO2=21% With Flow=25-35LPM | Perceived Level of Exertion Change | T4 | 5.87 units on a scale (0-10) | Standard Deviation 2.5 |
| FiO2=21% With Flow=25-35LPM | Perceived Level of Exertion Change | T0 | 7.86 units on a scale (0-10) | Standard Deviation 2.8 |
| FiO2=21% With Flow=25-35LPM | Perceived Level of Exertion Change | T30 | 1.47 units on a scale (0-10) | Standard Deviation 1.64 |
| FiO2=21% With Flow=25-35LPM | Perceived Level of Exertion Change | T25 | 1.93 units on a scale (0-10) | Standard Deviation 1.87 |
| FiO2=21% With Flow=25-35LPM | Perceived Level of Exertion Change | T10 | 3.67 units on a scale (0-10) | Standard Deviation 2.53 |
| FiO2=21% With Flow=25-35LPM | Perceived Level of Exertion Change | T8 | 4.13 units on a scale (0-10) | Standard Deviation 2.75 |
| FiO2=21% With Flow=25-35LPM | Perceived Level of Exertion Change | T2 | 6.87 units on a scale (0-10) | Standard Deviation 2.47 |
| FiO2=21% With Flow=25-35LPM | Perceived Level of Exertion Change | T50 | .93 units on a scale (0-10) | Standard Deviation 1.03 |
| FiO2=21% With Flow=25-35LPM | Perceived Level of Exertion Change | T15 | 2.67 units on a scale (0-10) | Standard Deviation 2.19 |
| FiO2=100% With Flow=5LPM | Perceived Level of Exertion Change | T40 | 1.13 units on a scale (0-10) | Standard Deviation 1.36 |
| FiO2=100% With Flow=5LPM | Perceived Level of Exertion Change | T6 | 5.00 units on a scale (0-10) | Standard Deviation 2.2 |
| FiO2=100% With Flow=5LPM | Perceived Level of Exertion Change | T8 | 3.87 units on a scale (0-10) | Standard Deviation 2.45 |
| FiO2=100% With Flow=5LPM | Perceived Level of Exertion Change | T60 | .71 units on a scale (0-10) | Standard Deviation 0.73 |
| FiO2=100% With Flow=5LPM | Perceived Level of Exertion Change | T10 | 3.47 units on a scale (0-10) | Standard Deviation 2.61 |
| FiO2=100% With Flow=5LPM | Perceived Level of Exertion Change | T15 | 2.60 units on a scale (0-10) | Standard Deviation 2.13 |
| FiO2=100% With Flow=5LPM | Perceived Level of Exertion Change | T50 | .93 units on a scale (0-10) | Standard Deviation 1.03 |
| FiO2=100% With Flow=5LPM | Perceived Level of Exertion Change | T20 | 2.20 units on a scale (0-10) | Standard Deviation 1.9 |
| FiO2=100% With Flow=5LPM | Perceived Level of Exertion Change | T25 | 1.80 units on a scale (0-10) | Standard Deviation 1.78 |
| FiO2=100% With Flow=5LPM | Perceived Level of Exertion Change | T30 | 1.67 units on a scale (0-10) | Standard Deviation 1.68 |
| FiO2=100% With Flow=5LPM | Perceived Level of Exertion Change | T0 | 8.54 units on a scale (0-10) | Standard Deviation 1.98 |
| FiO2=100% With Flow=5LPM | Perceived Level of Exertion Change | T2 | 6.93 units on a scale (0-10) | Standard Deviation 2.02 |
| FiO2=100% With Flow=5LPM | Perceived Level of Exertion Change | T4 | 5.67 units on a scale (0-10) | Standard Deviation 2.13 |
| FiO2=100% With Flow=25-35LPM | Perceived Level of Exertion Change | T30 | 1.43 units on a scale (0-10) | Standard Deviation 1.55 |
| FiO2=100% With Flow=25-35LPM | Perceived Level of Exertion Change | T20 | 2.07 units on a scale (0-10) | Standard Deviation 1.79 |
| FiO2=100% With Flow=25-35LPM | Perceived Level of Exertion Change | T6 | 4.60 units on a scale (0-10) | Standard Deviation 1.68 |
| FiO2=100% With Flow=25-35LPM | Perceived Level of Exertion Change | T0 | 8.93 units on a scale (0-10) | Standard Deviation 1.33 |
| FiO2=100% With Flow=25-35LPM | Perceived Level of Exertion Change | T15 | 2.47 units on a scale (0-10) | Standard Deviation 2.07 |
| FiO2=100% With Flow=25-35LPM | Perceived Level of Exertion Change | T10 | 3.07 units on a scale (0-10) | Standard Deviation 2.19 |
| FiO2=100% With Flow=25-35LPM | Perceived Level of Exertion Change | T4 | 5.80 units on a scale (0-10) | Standard Deviation 1.47 |
| FiO2=100% With Flow=25-35LPM | Perceived Level of Exertion Change | T2 | 6.93 units on a scale (0-10) | Standard Deviation 1.75 |
| FiO2=100% With Flow=25-35LPM | Perceived Level of Exertion Change | T8 | 3.67 units on a scale (0-10) | Standard Deviation 2.29 |
| FiO2=100% With Flow=25-35LPM | Perceived Level of Exertion Change | T25 | 1.67 units on a scale (0-10) | Standard Deviation 1.54 |
| FiO2=100% With Flow=25-35LPM | Perceived Level of Exertion Change | T60 | .93 units on a scale (0-10) | Standard Deviation 0.96 |
| FiO2=100% With Flow=25-35LPM | Perceived Level of Exertion Change | T50 | 1.07 units on a scale (0-10) | Standard Deviation 1.22 |
| FiO2=100% With Flow=25-35LPM | Perceived Level of Exertion Change | T40 | 1.13 units on a scale (0-10) | Standard Deviation 1.19 |
Secondary
Respiratory Rate Change
The change in respiratory rate starting from the exercise test throughout the recovery period
Time frame: Prior to the Wingate test (TR) and after at 1min (T1), 2min (T2), 4min (T4), 6min (T6), 8min (T8), 10min (T10), 15min (T15), 20min (T20), 25min (T25), 30min (T30), 40min (T40), 50 min (T50), and 60min (T60) into recovery.
Population: Subjects that had the data collected for the specified time point.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| FiO2=21% With Flow=5LPM | Respiratory Rate Change | T15 | 19.12 Breaths per min | Standard Deviation 5.17 |
| FiO2=21% With Flow=5LPM | Respiratory Rate Change | T8 | 20.33 Breaths per min | Standard Deviation 6.84 |
| FiO2=21% With Flow=5LPM | Respiratory Rate Change | T6 | 22.98 Breaths per min | Standard Deviation 5.81 |
| FiO2=21% With Flow=5LPM | Respiratory Rate Change | T4 | 25.53 Breaths per min | Standard Deviation 5.95 |
| FiO2=21% With Flow=5LPM | Respiratory Rate Change | T20 | 17.89 Breaths per min | Standard Deviation 5.56 |
| FiO2=21% With Flow=5LPM | Respiratory Rate Change | TR | 14.04 Breaths per min | Standard Deviation 4.71 |
| FiO2=21% With Flow=5LPM | Respiratory Rate Change | T60 | 14.03 Breaths per min | Standard Deviation 3.24 |
| FiO2=21% With Flow=5LPM | Respiratory Rate Change | T40 | 15.09 Breaths per min | Standard Deviation 4.82 |
| FiO2=21% With Flow=5LPM | Respiratory Rate Change | T30 | 16.01 Breaths per min | Standard Deviation 4.66 |
| FiO2=21% With Flow=5LPM | Respiratory Rate Change | T1 | 29.01 Breaths per min | Standard Deviation 5.19 |
| FiO2=21% With Flow=5LPM | Respiratory Rate Change | T50 | 14.03 Breaths per min | Standard Deviation 4.19 |
| FiO2=21% With Flow=5LPM | Respiratory Rate Change | T25 | 16.20 Breaths per min | Standard Deviation 5.9 |
| FiO2=21% With Flow=5LPM | Respiratory Rate Change | T10 | 21.20 Breaths per min | Standard Deviation 4.19 |
| FiO2=21% With Flow=5LPM | Respiratory Rate Change | T2 | 25.63 Breaths per min | Standard Deviation 6.81 |
| FiO2=21% With Flow=25-35LPM | Respiratory Rate Change | T2 | 25.97 Breaths per min | Standard Deviation 5.45 |
| FiO2=21% With Flow=25-35LPM | Respiratory Rate Change | T15 | 16.19 Breaths per min | Standard Deviation 3.91 |
| FiO2=21% With Flow=25-35LPM | Respiratory Rate Change | TR | 14.35 Breaths per min | Standard Deviation 3.91 |
| FiO2=21% With Flow=25-35LPM | Respiratory Rate Change | T1 | 25.05 Breaths per min | Standard Deviation 7.34 |
| FiO2=21% With Flow=25-35LPM | Respiratory Rate Change | T4 | 22.47 Breaths per min | Standard Deviation 6.85 |
| FiO2=21% With Flow=25-35LPM | Respiratory Rate Change | T6 | 20.18 Breaths per min | Standard Deviation 5.97 |
| FiO2=21% With Flow=25-35LPM | Respiratory Rate Change | T8 | 18.04 Breaths per min | Standard Deviation 4.78 |
| FiO2=21% With Flow=25-35LPM | Respiratory Rate Change | T10 | 18.91 Breaths per min | Standard Deviation 4.2 |
| FiO2=21% With Flow=25-35LPM | Respiratory Rate Change | T20 | 14.05 Breaths per min | Standard Deviation 3.61 |
| FiO2=21% With Flow=25-35LPM | Respiratory Rate Change | T25 | 12.64 Breaths per min | Standard Deviation 4.4 |
| FiO2=21% With Flow=25-35LPM | Respiratory Rate Change | T30 | 12.00 Breaths per min | Standard Deviation 5.05 |
| FiO2=21% With Flow=25-35LPM | Respiratory Rate Change | T40 | 11.59 Breaths per min | Standard Deviation 3.01 |
| FiO2=21% With Flow=25-35LPM | Respiratory Rate Change | T50 | 11.43 Breaths per min | Standard Deviation 3.83 |
| FiO2=21% With Flow=25-35LPM | Respiratory Rate Change | T60 | 10.77 Breaths per min | Standard Deviation 3.64 |
| FiO2=100% With Flow=5LPM | Respiratory Rate Change | T8 | 19.02 Breaths per min | Standard Deviation 8.39 |
| FiO2=100% With Flow=5LPM | Respiratory Rate Change | T60 | 12.99 Breaths per min | Standard Deviation 4.85 |
| FiO2=100% With Flow=5LPM | Respiratory Rate Change | T10 | 18.35 Breaths per min | Standard Deviation 6.45 |
| FiO2=100% With Flow=5LPM | Respiratory Rate Change | T50 | 13.14 Breaths per min | Standard Deviation 6.73 |
| FiO2=100% With Flow=5LPM | Respiratory Rate Change | T20 | 16.51 Breaths per min | Standard Deviation 6.58 |
| FiO2=100% With Flow=5LPM | Respiratory Rate Change | T1 | 25.41 Breaths per min | Standard Deviation 8.02 |
| FiO2=100% With Flow=5LPM | Respiratory Rate Change | T25 | 16.61 Breaths per min | Standard Deviation 5.07 |
| FiO2=100% With Flow=5LPM | Respiratory Rate Change | T15 | 17.91 Breaths per min | Standard Deviation 5.31 |
| FiO2=100% With Flow=5LPM | Respiratory Rate Change | T30 | 12.91 Breaths per min | Standard Deviation 4.45 |
| FiO2=100% With Flow=5LPM | Respiratory Rate Change | TR | 15.24 Breaths per min | Standard Deviation 5.93 |
| FiO2=100% With Flow=5LPM | Respiratory Rate Change | T40 | 12.92 Breaths per min | Standard Deviation 4.31 |
| FiO2=100% With Flow=5LPM | Respiratory Rate Change | T4 | 22.63 Breaths per min | Standard Deviation 6.67 |
| FiO2=100% With Flow=5LPM | Respiratory Rate Change | T6 | 20.04 Breaths per min | Standard Deviation 7.25 |
| FiO2=100% With Flow=5LPM | Respiratory Rate Change | T2 | 25.59 Breaths per min | Standard Deviation 6.02 |
| FiO2=100% With Flow=25-35LPM | Respiratory Rate Change | T40 | 12.46 Breaths per min | Standard Deviation 4.68 |
| FiO2=100% With Flow=25-35LPM | Respiratory Rate Change | T1 | 27.3 Breaths per min | Standard Deviation 5.53 |
| FiO2=100% With Flow=25-35LPM | Respiratory Rate Change | T30 | 12.68 Breaths per min | Standard Deviation 4.56 |
| FiO2=100% With Flow=25-35LPM | Respiratory Rate Change | T15 | 15.17 Breaths per min | Standard Deviation 7.04 |
| FiO2=100% With Flow=25-35LPM | Respiratory Rate Change | T10 | 17.51 Breaths per min | Standard Deviation 5.72 |
| FiO2=100% With Flow=25-35LPM | Respiratory Rate Change | T60 | 10.83 Breaths per min | Standard Deviation 2.86 |
| FiO2=100% With Flow=25-35LPM | Respiratory Rate Change | T6 | 19.09 Breaths per min | Standard Deviation 5.83 |
| FiO2=100% With Flow=25-35LPM | Respiratory Rate Change | T20 | 14.32 Breaths per min | Standard Deviation 5.54 |
| FiO2=100% With Flow=25-35LPM | Respiratory Rate Change | T8 | 17.84 Breaths per min | Standard Deviation 6.8 |
| FiO2=100% With Flow=25-35LPM | Respiratory Rate Change | T50 | 10.81 Breaths per min | Standard Deviation 3.94 |
| FiO2=100% With Flow=25-35LPM | Respiratory Rate Change | T4 | 21.39 Breaths per min | Standard Deviation 6.29 |
| FiO2=100% With Flow=25-35LPM | Respiratory Rate Change | T25 | 13.07 Breaths per min | Standard Deviation 4.9 |
| FiO2=100% With Flow=25-35LPM | Respiratory Rate Change | TR | 13.59 Breaths per min | Standard Deviation 3.79 |
| FiO2=100% With Flow=25-35LPM | Respiratory Rate Change | T2 | 22.73 Breaths per min | Standard Deviation 6.52 |
Secondary
SpO2 Change
The change in SpO2 starting from the exercise test throughout the recovery period.
Time frame: Prior to the Wingate test (TR) and after at, 2min (T2), 4min (T4), 6min (T6), 8min (T8), 10min (T10), 15min (T15), 20min (T20), 25min (T25), 30min (T30), 40min (T40), 50 min (T50), and 60min (T60) into recovery.
Population: Subjects that had the data collected at that specified time point.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| FiO2=21% With Flow=5LPM | SpO2 Change | T60 | 96.00 Percent oxygen | Standard Deviation 1.41 |
| FiO2=21% With Flow=5LPM | SpO2 Change | T20 | 96.53 Percent oxygen | Standard Deviation 1.06 |
| FiO2=21% With Flow=5LPM | SpO2 Change | T25 | 96.47 Percent oxygen | Standard Deviation 1.19 |
| FiO2=21% With Flow=5LPM | SpO2 Change | T50 | 96.00 Percent oxygen | Standard Deviation 1.2 |
| FiO2=21% With Flow=5LPM | SpO2 Change | T30 | 95.80 Percent oxygen | Standard Deviation 1.15 |
| FiO2=21% With Flow=5LPM | SpO2 Change | T4 | 97.73 Percent oxygen | Standard Deviation 1.1 |
| FiO2=21% With Flow=5LPM | SpO2 Change | T6 | 97.73 Percent oxygen | Standard Deviation 0.96 |
| FiO2=21% With Flow=5LPM | SpO2 Change | TR | 99.07 Percent oxygen | Standard Deviation 0.8 |
| FiO2=21% With Flow=5LPM | SpO2 Change | T8 | 97.00 Percent oxygen | Standard Deviation 1.31 |
| FiO2=21% With Flow=5LPM | SpO2 Change | T10 | 97.20 Percent oxygen | Standard Deviation 1.08 |
| FiO2=21% With Flow=5LPM | SpO2 Change | T40 | 96.00 Percent oxygen | Standard Deviation 1.89 |
| FiO2=21% With Flow=5LPM | SpO2 Change | T2 | 98.20 Percent oxygen | Standard Deviation 0.94 |
| FiO2=21% With Flow=5LPM | SpO2 Change | T15 | 96.87 Percent oxygen | Standard Deviation 0.99 |
| FiO2=21% With Flow=25-35LPM | SpO2 Change | T40 | 95.73 Percent oxygen | Standard Deviation 1.22 |
| FiO2=21% With Flow=25-35LPM | SpO2 Change | T2 | 98.13 Percent oxygen | Standard Deviation 1.13 |
| FiO2=21% With Flow=25-35LPM | SpO2 Change | T6 | 96.80 Percent oxygen | Standard Deviation 1.52 |
| FiO2=21% With Flow=25-35LPM | SpO2 Change | T20 | 96.43 Percent oxygen | Standard Deviation 0.94 |
| FiO2=21% With Flow=25-35LPM | SpO2 Change | T60 | 95.87 Percent oxygen | Standard Deviation 1.41 |
| FiO2=21% With Flow=25-35LPM | SpO2 Change | T4 | 97.53 Percent oxygen | Standard Deviation 1.13 |
| FiO2=21% With Flow=25-35LPM | SpO2 Change | T50 | 96.27 Percent oxygen | Standard Deviation 1.33 |
| FiO2=21% With Flow=25-35LPM | SpO2 Change | T25 | 95.87 Percent oxygen | Standard Deviation 1.55 |
| FiO2=21% With Flow=25-35LPM | SpO2 Change | T15 | 96.33 Percent oxygen | Standard Deviation 0.9 |
| FiO2=21% With Flow=25-35LPM | SpO2 Change | TR | 98.71 Percent oxygen | Standard Deviation 1.14 |
| FiO2=21% With Flow=25-35LPM | SpO2 Change | T10 | 96.60 Percent oxygen | Standard Deviation 0.83 |
| FiO2=21% With Flow=25-35LPM | SpO2 Change | T30 | 96.00 Percent oxygen | Standard Deviation 1.2 |
| FiO2=21% With Flow=25-35LPM | SpO2 Change | T8 | 96.87 Percent oxygen | Standard Deviation 0.99 |
| FiO2=100% With Flow=5LPM | SpO2 Change | T30 | 97.73 Percent oxygen | Standard Deviation 0.96 |
| FiO2=100% With Flow=5LPM | SpO2 Change | T40 | 98.87 Percent oxygen | Standard Deviation 0.64 |
| FiO2=100% With Flow=5LPM | SpO2 Change | T50 | 98.13 Percent oxygen | Standard Deviation 0.64 |
| FiO2=100% With Flow=5LPM | SpO2 Change | T4 | 98.53 Percent oxygen | Standard Deviation 0.83 |
| FiO2=100% With Flow=5LPM | SpO2 Change | T60 | 97.71 Percent oxygen | Standard Deviation 0.73 |
| FiO2=100% With Flow=5LPM | SpO2 Change | TR | 98.13 Percent oxygen | Standard Deviation 1.6 |
| FiO2=100% With Flow=5LPM | SpO2 Change | T6 | 98.27 Percent oxygen | Standard Deviation 1.1 |
| FiO2=100% With Flow=5LPM | SpO2 Change | T8 | 98.33 Percent oxygen | Standard Deviation 0.9 |
| FiO2=100% With Flow=5LPM | SpO2 Change | T10 | 98.27 Percent oxygen | Standard Deviation 0.88 |
| FiO2=100% With Flow=5LPM | SpO2 Change | T15 | 98.13 Percent oxygen | Standard Deviation 0.74 |
| FiO2=100% With Flow=5LPM | SpO2 Change | T20 | 98.13 Percent oxygen | Standard Deviation 0.74 |
| FiO2=100% With Flow=5LPM | SpO2 Change | T2 | 98.47 Percent oxygen | Standard Deviation 1.46 |
| FiO2=100% With Flow=5LPM | SpO2 Change | T25 | 98.00 Percent oxygen | Standard Deviation 0.76 |
| FiO2=100% With Flow=25-35LPM | SpO2 Change | T60 | 98.07 Percent oxygen | Standard Deviation 2.37 |
| FiO2=100% With Flow=25-35LPM | SpO2 Change | TR | 98.49 Percent oxygen | Standard Deviation 0.99 |
| FiO2=100% With Flow=25-35LPM | SpO2 Change | T2 | 99.33 Percent oxygen | Standard Deviation 0.72 |
| FiO2=100% With Flow=25-35LPM | SpO2 Change | T4 | 99.00 Percent oxygen | Standard Deviation 0.85 |
| FiO2=100% With Flow=25-35LPM | SpO2 Change | T6 | 99.00 Percent oxygen | Standard Deviation 0.85 |
| FiO2=100% With Flow=25-35LPM | SpO2 Change | T10 | 98.47 Percent oxygen | Standard Deviation 1.46 |
| FiO2=100% With Flow=25-35LPM | SpO2 Change | T15 | 98.27 Percent oxygen | Standard Deviation 1.33 |
| FiO2=100% With Flow=25-35LPM | SpO2 Change | T20 | 98.47 Percent oxygen | Standard Deviation 0.74 |
| FiO2=100% With Flow=25-35LPM | SpO2 Change | T25 | 98.00 Percent oxygen | Standard Deviation 1.41 |
| FiO2=100% With Flow=25-35LPM | SpO2 Change | T30 | 98.27 Percent oxygen | Standard Deviation 0.96 |
| FiO2=100% With Flow=25-35LPM | SpO2 Change | T40 | 97.60 Percent oxygen | Standard Deviation 2.38 |
| FiO2=100% With Flow=25-35LPM | SpO2 Change | T50 | 98.00 Percent oxygen | Standard Deviation 1.89 |
| FiO2=100% With Flow=25-35LPM | SpO2 Change | T8 | 98.87 Percent oxygen | Standard Deviation 0.64 |
Secondary
Systolic Blood Pressure Change
The change in systolic blood pressure starting from the exercise test throughout the recovery period.
Time frame: Prior to the Wingate test (TR) and after at, 5min (T5) 10min (T10), 15min (T15), 20min (T20), 25min (T25), 30min (T30), 40min (T40), 50 min (T50), and 60min (T60) into recovery.
Population: Subjects that had this data collected for the specified time point.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| FiO2=21% With Flow=5LPM | Systolic Blood Pressure Change | T5 | 132.87 mmHG | Standard Deviation 17.11 |
| FiO2=21% With Flow=5LPM | Systolic Blood Pressure Change | T15 | 124.31 mmHG | Standard Deviation 15.48 |
| FiO2=21% With Flow=5LPM | Systolic Blood Pressure Change | T20 | 117.93 mmHG | Standard Deviation 17.26 |
| FiO2=21% With Flow=5LPM | Systolic Blood Pressure Change | T10 | 124.14 mmHG | Standard Deviation 15.03 |
| FiO2=21% With Flow=5LPM | Systolic Blood Pressure Change | T60 | 114.07 mmHG | Standard Deviation 12.46 |
| FiO2=21% With Flow=5LPM | Systolic Blood Pressure Change | T40 | 114.33 mmHG | Standard Deviation 14.94 |
| FiO2=21% With Flow=5LPM | Systolic Blood Pressure Change | TR | 125.73 mmHG | Standard Deviation 16.88 |
| FiO2=21% With Flow=5LPM | Systolic Blood Pressure Change | T50 | 117.47 mmHG | Standard Deviation 21.23 |
| FiO2=21% With Flow=5LPM | Systolic Blood Pressure Change | T30 | 115.40 mmHG | Standard Deviation 12.07 |
| FiO2=21% With Flow=5LPM | Systolic Blood Pressure Change | T25 | 116.60 mmHG | Standard Deviation 14.27 |
| FiO2=21% With Flow=25-35LPM | Systolic Blood Pressure Change | T10 | 123.47 mmHG | Standard Deviation 13.94 |
| FiO2=21% With Flow=25-35LPM | Systolic Blood Pressure Change | T15 | 120.93 mmHG | Standard Deviation 13.79 |
| FiO2=21% With Flow=25-35LPM | Systolic Blood Pressure Change | TR | 126.27 mmHG | Standard Deviation 8.49 |
| FiO2=21% With Flow=25-35LPM | Systolic Blood Pressure Change | T5 | 138.57 mmHG | Standard Deviation 20.49 |
| FiO2=21% With Flow=25-35LPM | Systolic Blood Pressure Change | T20 | 118.93 mmHG | Standard Deviation 13.65 |
| FiO2=21% With Flow=25-35LPM | Systolic Blood Pressure Change | T25 | 117.86 mmHG | Standard Deviation 10.74 |
| FiO2=21% With Flow=25-35LPM | Systolic Blood Pressure Change | T30 | 116.67 mmHG | Standard Deviation 10.19 |
| FiO2=21% With Flow=25-35LPM | Systolic Blood Pressure Change | T40 | 114.93 mmHG | Standard Deviation 11.16 |
| FiO2=21% With Flow=25-35LPM | Systolic Blood Pressure Change | T50 | 114.47 mmHG | Standard Deviation 9.77 |
| FiO2=21% With Flow=25-35LPM | Systolic Blood Pressure Change | T60 | 114.47 mmHG | Standard Deviation 11.12 |
| FiO2=100% With Flow=5LPM | Systolic Blood Pressure Change | T40 | 116.60 mmHG | Standard Deviation 12.89 |
| FiO2=100% With Flow=5LPM | Systolic Blood Pressure Change | T10 | 126.47 mmHG | Standard Deviation 12.72 |
| FiO2=100% With Flow=5LPM | Systolic Blood Pressure Change | T30 | 116.87 mmHG | Standard Deviation 13.33 |
| FiO2=100% With Flow=5LPM | Systolic Blood Pressure Change | T60 | 114.86 mmHG | Standard Deviation 9.43 |
| FiO2=100% With Flow=5LPM | Systolic Blood Pressure Change | T25 | 114.20 mmHG | Standard Deviation 10.69 |
| FiO2=100% With Flow=5LPM | Systolic Blood Pressure Change | T15 | 124.86 mmHG | Standard Deviation 13.2 |
| FiO2=100% With Flow=5LPM | Systolic Blood Pressure Change | T5 | 136.53 mmHG | Standard Deviation 16.25 |
| FiO2=100% With Flow=5LPM | Systolic Blood Pressure Change | T50 | 115.87 mmHG | Standard Deviation 10.49 |
| FiO2=100% With Flow=5LPM | Systolic Blood Pressure Change | T20 | 120.80 mmHG | Standard Deviation 15.79 |
| FiO2=100% With Flow=5LPM | Systolic Blood Pressure Change | TR | 125.20 mmHG | Standard Deviation 12.4 |
| FiO2=100% With Flow=25-35LPM | Systolic Blood Pressure Change | T20 | 120.79 mmHG | Standard Deviation 15.49 |
| FiO2=100% With Flow=25-35LPM | Systolic Blood Pressure Change | T50 | 1113.93 mmHG | Standard Deviation 11.32 |
| FiO2=100% With Flow=25-35LPM | Systolic Blood Pressure Change | T25 | 115.07 mmHG | Standard Deviation 13.37 |
| FiO2=100% With Flow=25-35LPM | Systolic Blood Pressure Change | T30 | 114.07 mmHG | Standard Deviation 14.03 |
| FiO2=100% With Flow=25-35LPM | Systolic Blood Pressure Change | T60 | 113.67 mmHG | Standard Deviation 11.31 |
| FiO2=100% With Flow=25-35LPM | Systolic Blood Pressure Change | T40 | 113.93 mmHG | Standard Deviation 8.34 |
| FiO2=100% With Flow=25-35LPM | Systolic Blood Pressure Change | T10 | 125.20 mmHG | Standard Deviation 15.84 |
| FiO2=100% With Flow=25-35LPM | Systolic Blood Pressure Change | T5 | 133.93 mmHG | Standard Deviation 13.6 |
| FiO2=100% With Flow=25-35LPM | Systolic Blood Pressure Change | T15 | 124.46 mmHG | Standard Deviation 12.76 |
| FiO2=100% With Flow=25-35LPM | Systolic Blood Pressure Change | TR | 121.33 mmHG | Standard Deviation 10.47 |