Post Intensive Care Syndrome
Conditions
Keywords
Intensive Care Unit, frailty, fatigue, ICU acquired-weakness, FACIT-F, physical activity
Brief summary
After a prolonged stay in Intensive Care Unit (ICU), fatigue is the most common symptom reported by patients in the Post Intensive Care Syndrome (PICS). Other complications have been described, including ICU-acquired weakness, leading to increased morbidity and mortality after discharge. Actually, risk factors associated with post-ICU fatigue self-reported are not really known.
Detailed description
Frailty, defined as a decrease in physiological reserves leading to an alteration in the mechanisms of adaptation to stress, increases the incidence of PICS and could therefore be a cause of post-ICU fatigue self-reported. The aim of this study is to identify a relationship between markers of frailty, ICU-AW, ICU story and the post-ICU fatigue self-reported 6 months discharge in patients with prolonged ICU stays.
Interventions
OTHERobservational prospective data collection
Collection of data from medical records.
Sponsors
Centre Hospitalier Universitaire de Saint Etienne
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with a length of stay in intensive care \> or equal to 7 days, or mechanical ventilation \> or equal to 5 days
Exclusion criteria
* Scheduled surgery with admission in ICU * Pregnancy * Guardianship
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Frailty | 1 year | Relationship between frailty markers (CFS, IADL, sarcopenia and myosteatosis), ICU-AW, ICU story and post-ICU fatigue self-reported |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Fatigue | 1 year | Prevalence of post-ICU fatigue self-reported 6 months discharge in prospective cohort |
| ICU-acquired weakness and fatigue | 1 year | Correlation between post-ICU fatigue self-reported and muscular strength assessed by handgrip test |
| Fatigue, quality of life, anxiety and depressive disorder | 1 year | Correlation between fatigue, quality of life, anxiety and depressive disorder |
| Kinetic of muscle mass loss and post-ICU fatigue self-reported | 1 year | Correlation between the kinetic of muscle mass loss and post-ICU fatigue self-reported |
Countries
France
Contacts
Primary ContactJérôme MOREL, MD PhD
Backup ContactNory ELHADJENE, MD
Outcome results
None listed