Endometriosis
Conditions
Keywords
Quercetin, Endometriosis, Inflammation, Gonadal Steroid Hormones, Anthropometric, Adiponectin, Growth factor, Metabolic factors
Brief summary
Quercetin is a polyphenol compound that possesses anti-inflammatory properties and can be found in various food sources like apples, berries, cabbage, and onions. In Park et al.'s study, it was discovered that quercetin led to a significant decrease in the proliferation of endometriosis cells. Furthermore, quercetin also triggered apoptosis in endometriosis cells in vitro and reduced the size of endometriosis lesions in vivo. Nevertheless, as of now, there have been no studies conducted in Iran or worldwide that explore the effects of quercetin supplementation on individuals with endometriosis. Hence, the aim of this study is to investigate the impact of quercetin supplementation on factors such as glycemic status, lipid profile, oxidative stress, inflammation, growth factors, adiponectin, sex hormones, and anthropometric indicators in women suffering from endometriosis.
Detailed description
The participants in the study were randomly assigned to two groups: the intervention group and the control group. The intervention group will receive two 500 mg quercetin tablets daily, after breakfast and lunch, for twelve weeks. On the other hand, the control group will be given a placebo. Blood samples will be collected before and after the intervention to measure changes in blood lipid profile, fasting blood sugar, sex hormones (testosterone, estrogen, progesterone), TNFα, IL-6, adiponectin, IGF1, HbA1C, SHBG, FSH, LH, and plasma total antioxidant capacity.
Interventions
DIETARY_SUPPLEMENTQuercetin
The intervention group will receive two 500 mg quercetin tablets daily, after breakfast and lunch, for twelve weeks.
OTHERPlacebo
The control group will receive two placebo daily, after breakfast and lunch, for twelve weeks.
Sponsors
Shahid Beheshti University of Medical Sciences
National Nutrition and Food Technology Institute
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Willing to cooperate and complete the informed consent form. * Diagnosed endometriosis using laparoscopy and histopathological tests. * In the age group of 18 to 40 years. * Having a regular menstrual cycle. * Having a body mass index between 18.5 and 30.
Exclusion criteria
* Using hormonal medications or intrauterine treatments for a minimum of three months prior to collecting a sample. * Having immune system disorders, persistent infections, diabetes, or any conditions like polyps and fibroids within the uterine cavity.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mean serum TNF-alpha concentration | 12 weeks | Human Tumor Necrosis Factor Αlpha, TNF-A ELISA Kit |
| Mean serum IL-6 concentration | 12 weeks | Human Interleukin 6, IL-6 ELISA Kit |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mean Serum Testosterone concentration | 12 weeks | The Testosterone ELISA Kits |
| Mean Serum Estrogen concentration | 12 weeks | The Total Estrogens ELISA Assay Kit |
| Mean Serum Adiponectin concentration | 12 weeks | Adiponectin Human ELISA Kit |
| Mean Serum IGF1 concentration | 12 weeks | IGF-1 ELISA Assay Kit |
| Mean Serum FBS concentration | 12 weeks | Glucose Test Kit |
| Mean Serum FSH concentration | 12 weeks | FSH (Human) ELISA Kit |
| Mean Serum LH concentration | 12 weeks | LH (Human) ELISA Kit |
| Mean Serum Progesterone concentration | 12 weeks | The Progesterone Enzyme Immunoassay Kit |
| Mean plasma total antioxidant capacity concentration | 12 weeks | Total Antioxidant Capacity ELISA Kit |
| Mean Serum SHBG concentration | 12 weeks | liquid chromatography-tandem mass spectrometry |
| Mean HbA1C Serum | 12 weeks | Human Hemoglobin A1c (HbA1c) Assay Kit |
Countries
Iran
Contacts
Primary ContactGhazaleh Eslamian, PhD
Outcome results
None listed