Healthy Volunteers
Conditions
Brief summary
The goal of the study was to identify the effect of CYP2C9 gene polymorphism in the Pakistani population. The main question it aims to answer were: * to evaluate the effect of this genetic polymorphism on the clinical efficacy of Ibuprofen * to evaluate the effect of this genetic polymorphism on the clinical tolerability of Ibuprofen Participants were prescribed Ibuprofen after molar tooth extraction.
Detailed description
The goal of this study was to identify the effect of CYP2C9\*3 gene polymorphism in the Pakistani population, due to the high prevalence of this variant in the Pakistani Population The main question it aims to answer were: * to evaluate the effect of this genetic polymorphism on the clinical efficacy of Ibuprofen * to evaluate the effect of this genetic polymorphism on the clinical tolerability of Ibuprofen Participants were prescribed Ibuprofen after molar tooth extraction. The blood samples of the participants were taken and further genotyping was performed using conventional tetraARMS PCR. The results were visualized by gel electrophoresis.
Interventions
DRUGIbuprofen 400 mg
Ibuprofen 400 mg TDS
DRUGPlacebo
Placebo tablet
Sponsors
Riphah International University
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Pakistani individuals * Absence of systemic diseases * Extractions required based on orthodontic, periodontal, and endodontic indications
Exclusion criteria
* history of bleeding or gastrointestinal ulcers * allergic to ibuprofen or other NSAIDs. * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Visual Analogue Scale | three days | A Visual Analogue Scale (VAS) is one of the self-administered pain rating scales, to measure pain intensity. The pain was interpreted as no pain (0-4 mm), mild pain(5-44 mm), moderate pain (45-74 mm), and severe pain (75-100 mm). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| General Assessment of Side Effects scale | three days | The self-rating scale General Assessment of Side Effects (GASE), is about the most frequent side effects in clinical trials of different drugs. Every symptom (dyspepsia, nausea, diarrhea) had to be answered twice: first, participants had to rate the intensity of this symptom during the last 3 days, and second, if this symptom was present, participants had to rate whether they attribute it to current drug intake. |
Countries
Pakistan
Contacts
PRINCIPAL_INVESTIGATORAmmarah Amjad, BDS
Riphah International University
Outcome results
None listed