Demyelinating Autoimmune Diseases, CNS, Multiple Sclerosis, Neuromyelitis Optica
Conditions
Brief summary
In this protocol, a combination of MRI, blood, and cerebrospinal fluid (CSF) analysis will be used to understand the natural history, underlying immunologic mechanisms, and clinical implications of central nervous system (CNS) lesions, in particular lesions in the cerebral cortex, in multiple sclerosis (MS) and other inflammatory and autoimmune disorders affecting the CNS. Patients with these disorders, as well as healthy controls, will undergo baseline clinical evaluation and testing, bloodwork, and MRI, with follow up clinical evaluation, bloodwork, and MRI at years 1, 3, and 6. Additional MRIs may be performed in patients with possible new lesion formation or to compare MRI techniques. Lumbar puncture will be performed on participants who are not currently being treated with disease modifying therapies and who are willing to undergo the procedure.
Interventions
None listed
Sponsors
Icahn School of Medicine at Mount Sinai
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* 18 years old * able to provide consent in English * able to undergo MRI
Exclusion criteria
* contraindication to MRI * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cortical Lesion Number | at 6 years (end of study) | Lesions in the cerebral cortex |
Countries
United States
Contacts
CONTACTErin S Beck, MD, PhD
PRINCIPAL_INVESTIGATORErin S Beck, MD, PhD
Icahn School of Medicine at Mount Sinai
Outcome results
None listed