Acute Kidney Injury Due to Sepsis, Lithium Clearance, Proximal Tubule Function
Conditions
Brief summary
Critically ill patients are at high risk of developing acute kidney injury (AKI). Lithium is freely filtrated at the glomerulus and almost completely reabsorbed in the proximal tubule, which provides a quantitative estimation of proximal tubule reabsorption. The investigators hypothesized that endogenous lithium reabsorption is impaired in the early stages of critical illness. Investigators would like to study 10 ICU patients with AKI diagnosed, 10 patients without AKI, and 10 healthy controls.
Detailed description
Blood and urine samples will be obtained at 08:00, 14:00 and 20:00 during one day. Renal clearance of creatinine (CCr) and lithium will be calculated.
Interventions
DIAGNOSTIC_TESTLithium clearance
Blood and urine samples
Sponsors
University Hospital of North Norway
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* ICU patients diagnosed with AKI, without AKI and healthy controls
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Renal lithium clearance | 2 days | Clearance of lithium from the body |
Countries
Norway
Outcome results
None listed