Curcumin Gel On Radiation Induced Oral Mucositis

The Effect of Curcuma Long Oral Gel in Relation to Salivary Epidermal Growth Factor & Interleukin-8 on Radiation Induced Oral Mucositis in Iraqi Cancer Patients

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05982197

Enrollment

Registered

2023-08-08

Start date

2023-01-03

Completion date

2023-07-02

Last updated

2023-08-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Head and Neck Cancer, Radiation-Induced Mucositis

Keywords

Radiation induced oral mucositis, Head and neck cancer, Curcuma longa, EGF, IL8

Brief summary

The goal of this clinical study is to investigate the effect of a curcuma longa oral gel (curenext) on reducing radiation-induced oral mucositis severity in cancer patients and provide a context for understanding if there is a relationship between the curcumin clinical effect and production of EGFs and IL8. Researchers will compare between curcumin group and standard treatment group.

Interventions

DRUGCurcumin Gel

Curcuma longa oral gel for prevention radiation induced oral mucositis

DRUGStandard Preparation

Standard preparation for prevention radiation induced oral mucositis

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Intervention model description

Two groups A) curcuma longa oral gel group B) standard treatment group

Eligibility

Sex/Gender

ALL

Age

16 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Patients above 16 years having histopathologically confirmed cancer in head and neck region who planned to have radiation with head and neck mask. * Scheduled for 6-8 weeks of radiotherapy with 60-70Gy radiation (200cgy/fraction for 5 days/week).

Exclusion criteria

* patient with hodgkin lymphoma. * Any allergy to curcumin or other condiments.

Design outcomes

Primary

Measure	Time frame	Description
Onset of radiation induced mucositis	Assessment every week starting from first visit until the onset of mucositis (up to 2 months)	Onset (at which week) of radiation induced mucositis in relation to EGF and IL8
Change in severity of radiation induced mucositis	Assessment every week starting from first visit of radiation unit it completion (average of 2 months)	Change in severity (degree of illness) of radiation induced mucositis in relation to EGF & IL-8 by World Health Organization (WHO) mucositis scale {0: no. 1: mild. 2 and 3 : moderate. 4: severe}

Countries

Iraq

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026