Cytokine, Intervertebral Disc, Degenerative
Conditions
Keywords
cytokine, chemokine, Intervertebral Disc Degeneration
Brief summary
Low back pain (LBP) is the largest cause of morbidity in the world, and about 80% of Chinese people are affected in their lifetime. Although the prevalence of IDD gradually increases with age, IDD is very common among subjects under 30 years old. In addition to age, there are other factors, such as excessive or uneven mechanical load, obesity, genetics, nutrition, trauma and gender. In addition, it is not clear whether the heavy physical load associated with occupation is an important risk factor for IDD. Some studies have found that IDD is more common among athletes than the general population. Due to the complexity and multifactorial nature of IDD, its pathogenesis and risk factors are still unclear, which seriously hinders the rational stratification of LBP patients and limits the development of personalized treatment.
Interventions
DIAGNOSTIC_TESTCXCL2/CXCL8
Detecte CXCL2/8 content in nucleus pulposus and peripheral blood of patients in each group
Sponsors
Zhongda Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* It meets the diagnostic criteria of lumbar disc degeneration; No previous history of spinal surgery; Good ability of independent behavior and cooperation in completing research; The patient is aware of this study and has signed the consent form.
Exclusion criteria
* Patients with spinal tumor, infection, tuberculosis and other diseases; Patients with claustrophobia; Parkinson's syndrome patients; Poor cooperation, Poor image quality; Patients with osteoporosis.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| CXCL2/8 content | 1 month | CXCL2/CXCL8 content of nucleus pulposus |
Countries
China
Outcome results
None listed