Blood Pressure
Conditions
Brief summary
The goal of this clinical trial is to examine the effect of short-term L-Citrulline on central and peripheral blood pressure in healthy older adults. The main questions it aims to answer are: * Does L-citrulline favorably affect blood pressure at rest and during exercise? * Does L-citrulline favorably affect arterial stiffness? * Does L-citrulline favorably affect muscle oxygenation at rest and during exercise? Participants will be asked to consume L-citrulline and a placebo for six days and participate in the evaluation of their blood pressure, arterial stiffness, and muscle oxygenation before and after each intervention. Researchers will compare L-citrulline and placebo groups to examine whether L-citrulline supplementation affects the above health parameters.
Interventions
DIETARY_SUPPLEMENTL-Citrulline
6 g (3 g every 12 h) of L-citrulline for six days
DIETARY_SUPPLEMENTPlacebo
6 g (3 g every 12 h) of maltodextrin for six days
Sponsors
European University Cyprus
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
55 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* subject provides written informed consent. * normal health profile.
Exclusion criteria
* history of musculoskeletal injury in the legs during the previous six months. * smoker. * consumption of any medication the last three months. * consumption of any nutritional supplement the last three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in aortic and brachial systolic blood pressure (rest) | Change from baseline aortic and brachial systolic blood pressure at 7 days. |
| Change in aortic and brachial systolic blood pressure | Change from baseline aortic and brachial systolic blood pressure at the second minute of exercise. |
| Change in carotid-femoral pulse wave velocity (cfPWV) (rest) | Change from baseline aortic and brachial systolic blood pressure at 7 days. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in augmentation index (rest) | Change from baseline augmentation index at 7 days. | — |
| Change in forward and backward wave pressure (rest) | Change from baseline forward and backward wave pressure at 7 days. | — |
| Change in muscle oxyhemoglobin (rest) | Change from baseline oxyhemoglobin at 7 days. | — |
| Change in pulse pressure (exercise) | Change from baseline pulse pressure at the second minute of exercise. | — |
| Change in heart rate (exercise) | Change from baseline heart rate at the second minute of exercise. | — |
| Change in pulse pressure (rest) | Change from baseline pulse pressure at 7 days. | — |
| Change in augmentation index (exercise) | Change from baseline augmentation index at the second minute of exercise. | The ideal augmentation index is between 20 and 80. Values above 80 are considered high, and above 121 indicate high arterial stiffness. |
| Change in forward and backward wave pressure (exercise) | Change from baseline forward and backward wave pressure at the second minute of exercise. | — |
| Change in muscle deoxyhemoglobin (exercise) | Change from baseline muscle deoxyhemoglobin at the second minute of exercise. | — |
| Change in muscle deoxyhemoglobin (rest) | Change from baseline muscle deoxyhemoglobin at 7 days. | — |
| Change in muscle oxyhemoglobin (exercise) | Change from baseline muscle oxyhemoglobin at the second minute of exercise. | — |
| Change in augmented pressure (exercise) | Change from baseline augmented pressure at the second minute of exercise. | — |
| Change in heart rate (rest) | Change from baseline heart rate at 7 days. | — |
| Change in augmented pressure (rest) | Change from baseline augmented pressure at 7 days. | — |
Countries
Cyprus
Outcome results
None listed