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Evaluation of the Level of Oxidative Stress in Relation to the Type of Anesthesia in Parturients Whose Delivery Was Completed by Caesarean Section

Evaluation of the Level of Oxidative Stress in Relation to the Type of Anesthesia in Parturients Whose Delivery Was Completed by Caesarean Section

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05973435
Enrollment
100
Registered
2023-08-02
Start date
2023-03-01
Completion date
2023-10-01
Last updated
2023-12-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstetric Anesthesia Problems

Brief summary

The goal of this observational study is to assess the level of oxidative stress during cesarean section depending on the type of anesthesia applied and to determine the factors that can affect the level of oxidative stress. The main questions it aims to answer are: * is there any association between specific parameters of pregnancy, socio-demographic characteristics and laboratory analyses with an increased level of oxidative stress * is there any association between type of anesthesia for ceasarean section with an increased level of oxidative stress Blood sample would be taken from the participants in the study for these analyses on three occasions in 3 test tubes (before cesarean section, during cesarean section and after cesarean section). Researchers will compare patients that received general anesthesia with patients under spinal regional anesthesia to see if there is any difference in level of oxidative stress measured by laboratory parameters.

Interventions

OTHERBlood sampling

Blood sample would be taken from the participants in the study for these analyses on three occasions in 3 test tubes (before cesarean section, during cesarean section and after cesarean section).

Sponsors

University Clinic Dr Dragisa Misovic-Dedinje
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
FEMALE
Age
18 Years to 55 Years
Healthy volunteers
Yes

Inclusion criteria

* ASA status I and II

Exclusion criteria

* ASA status III and IV * Emergency C section

Design outcomes

Primary

MeasureTime frameDescription
Elevated level of oxidative stress2 hours after C sectionWe will measure enzymes of oxidative stress before cesarean section, during cesarean section and after cesarean section.

Secondary

MeasureTime frameDescription
Lactate level2 hours after C sectionWe will measure lactate levels before cesarean section, during cesarean section and after cesarean section.
Level of cortisol2 hours after C sectionWe will measure cortisol levels before cesarean section, during cesarean section and after cesarean section.

Countries

Serbia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026