IVF
Conditions
Keywords
Tadalafil, Sildenafil, pentoxyfylline, frozen embryo transfer
Brief summary
The aim of this study is to investigate the Effect of different vasodilators as Tadalafil, Sildenafil and pentoxyfylline in In vitro Fertilization. In addition, the thickness of endometrium and pregnancies rates of these women will also be examined. All adverse effects of all drugs will be estimated
Detailed description
A prospective randomized clinical study will be conducted in the IVF clinic of the gynecology department of Beni Suef University Hospital, Beni-Suef, Egypt. The study will These patients will be randomized into four groups. The participants will take drugs starting from the end of menstruation cycle till endometrium reach optimal and then will start progesterone 800 mg daily.
Interventions
DRUGtadalafil
tadalafil 10 mg one tablet daily
DRUGSildenafil
sildenafil 20 mg two tablets daily
DRUGpentoxifylline
pentoxifylline 400 mg two tabs daily
Sponsors
Beni-Suef University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* women having thawed embryos
Exclusion criteria
* hypotension * cardiovascular, hepatic, and renal diseases; * uncontrolled diabetes mellitus; * ovarian cysts; * hyperprolactinemia; * abnormal thyroid functions; * uterine fibroids; * patients taking nitrates; * endometriosis and adenomyosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| endometrial thickness | within 16 day of menstruation | measured by transvaginal ultrasound |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| pregnancy rate | 1 month | number of cases positive serum pregnancy test |
Countries
Egypt
Outcome results
None listed