Clearance of Asymptomatic Pharyngeal Carriage of Neisseria Gonorrhoeae With or Without Ceftriaxone Treatment: Randomized Non-inferiority Study

Inclusion criteria

Patients (n=154): Patient inclusion criteria : * Adult patient (age ≥ 18 years old) * Patient consulting for a pharyngeal Neisseria gonorrhoeae Sexually Transmitted Infection (STI) and meeting the following criteria : * Positive sample for NAAT by PCR in the pharynx for Neisseria gonorrhoeae dating back a maximum of 7 days (the date of the sample and those of inclusion will be compared) and * asymptomatic patient * Absence of symptoms of other bacterial STIs or other asymptomatic bacterial STIs confirmed on the systematic screening assessment carried out within 7 days before inclusion * Patient's agreement to use protection or abstinence from all oral sex for 3 months follow-up (experimental group) or for 7 days (control group) * For men whose female partner(s) are of childbearing age and for women of childbearing age: use of effective contraception (failure rate less than 1% per year) throughout research * Patient benefiting from a social health security scheme * Patient having signed a free and informed consent Patients non-inclusion criteria : * Minor patient * Symptomatic patient in the pharynx * Presence of symptoms of another bacterial STI or of an asymptomatic bacterial STI confirmed on the screening report carried out within 7 days before inclusion * Antibiotic treatment that may be active on Neisseria gonorrhoeae (C3G, Fluoroquinolones, Macrolides, Cyclins, Aminosides, Penicillins) within 14 days before inclusion * Hypersensitivity to ceftriaxone, other cephalosporins or to any of the excipients * History of severe hypersensitivity (e.g. anaphylactic reaction) to another class of antibacterial agents of the beta-lactam family (penicillins, monobactams and carbapenems). * Contraindication to ceftriaxone * Contraindication to intramuscular injections * Person under legal protection, under guardianship or curatorship, person deprived of liberty, under safeguard of justice, subject to psychiatric care, under duress, admitted to a health or social establishment for purposes other than those of research * Pregnant or breastfeeding woman * Lack of social health insurance * Patient included in another interventional study Partners (n=100) : Partner Inclusion Criteria : * Sexual contact of the index case (genito-anal or genito-vaginal, oro-genital or oro-anal or oro-oral relations) in the month preceding the inclusion of the index case * Adult patient (age ≥ 18 years old) * Patient benefiting from a social health security scheme * Patient having signed a free and informed consent Partner non-inclusion Criteria: * Minor patient * Person under legal protection, under guardianship or curatorship, person deprived of liberty, under safeguard of justice, subject to psychiatric care, under duress, admitted to a health or social establishment for purposes other than those of research * Patient included in another interventional study * Pregnant or breastfeeding woman