HCG Levels After Ovulation Triggering as Predictors of ICSI Outcome

Human Chorionic Gonadotropin Levels After Ovulation Triggering as Predictors of Intracytoplasmic Sperm Injection Outcome

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05969834

Enrollment

100

Registered

2023-08-01

Start date

2021-03-31

Completion date

2022-08-07

Last updated

2023-08-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Keywords

Ovulation triggering, uHCG, rHCG, GnRH, Dual trigger

Brief summary

This study aimed to assess the correlation between HCG levels after ovulation triggering and ICSI outcomes, affected by HCG formulation and dose

Detailed description

The aims of this study are: 1. To assess the correlation between serum human chorionic gonadotropin (hCG) level after ovulation triggering and intracytoplasmic sperm injection (ICSI) outcome including: oocyte maturity and quality, good quality embryo rate, blastocyst formation rate and pregnancy rate 2. To determine if there is an association between type and dose of the trigger and ICSI outcome.

Interventions

DRUGuHCG

Final oocyte maturation will be triggered by IM administration of 10000 IU of uHCG (Choriomon)

DRUGrHCG

Final oocyte maturation will be triggered by SC administration of 6500 IU of rHCG (Ovitrelle)

DRUGuHCG and GnRHa

Final oocyte maturation will be triggered by combined SC administration of 0.1 mg of GnRHa (Decapeptyl, Triptorelin) and IM administration of 2500 IU of uHCG (Choriomon)

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 35 Years

Healthy volunteers

Inclusion criteria

* Women who will undergo controlled ovarian stimulation (COS) through fixed GnRH antagonist protocol

Exclusion criteria

* BMI \> 30 kg/m2 * Irregular menstruation * Severe male factor abnormality * Poor ovarian reserve * Endometriosis * Uterine abnormality

Design outcomes

Primary

Measure	Time frame	Description
Clinical pregnancy rate	6 weeks after embryo transfer	Number of clinical pregnancies (defined as presence of at least one intrauterine gestational sac with fetal pole and cardiac activity on TVS scan at 4-6 weeks after the ET) divided by the number of ET procedures

Secondary

Measure	Time frame	Description
Oocyte maturation rate	On 1 day of oocyte retrieval	Number of mature oocytes divided by the number of retrieved oocytes

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026