Infertility, Female, IVF, Miscarriage, Miscarriage, Recurrent
Conditions
Keywords
miscarriage, infertility, IVF
Brief summary
This study aims to explore the potential correlation between decreased ovarian reserve and previous history of early miscarriage.
Detailed description
By investigating the prevalence of low ovarian reserve (LOR) in populations with specific reproductive histories (such as recurrent pregnancy loss, G0, and ectopic pregnancy), as well as the aneuploidy rates of embryos produced with Preimplantation Genetic Testing for Aneuploidies (PGT-A), Investigators can better understand how LOR impacts fertility outcomes in these populations. This information can be used to inform clinical decision-making, such as whether participants with LOR should consider alternative or whether they would benefit from additional interventions to improve ovarian function. Ultimately, by improving our understanding of how LOR impacts fertility outcomes in specific populations, Investigators can help to improve the overall success rates of infertility treatment, reduce anxiety, and distress, and help participants achieve goals of becoming parents.
Interventions
DIAGNOSTIC_TESTTransvaginal ultrasound
Transvaginal ultrasound for antral follicle count (AFC) performed on the day of first consultation
DIAGNOSTIC_TESTBlood test AMH
Measurement of AMH performed on the day of first consultation
Sponsors
ART Fertility Clinics LLC
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Inclusion criteria
1\. All participants with at least 1 previous pregnancy, who are assessed in one of our clinics (ART Fertility Clinics Abu Dhabi, Al Ain, Dubai)
Exclusion criteria
1. Severe male factor (azoospermia, cryptozoospermia, severe oligoasthenoteratozoospermia (OAT)) 2. Severe Endometriosis and adenomyosis based on positive anamnesis or ultrasound performed in our center during the first consultation 3. Uterine abnormalities (e.g. fibroids, different degrees of uterine septum), diagnosed by ultrasound 4. History of ovarian surgery, chemotherapy, or radiation therapy 5. Known genetic disorder or chromosomal abnormality 6. BMI \>40Kg/m2 7. Currently using hormonal contraception or hormone replacement therapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| AMH | 1 day | Anti-Müllerian Hormone Test |
| AFC | 1 day | Antral follicle count |
Countries
United Arab Emirates
Contacts
CONTACTBarbara Lawrenz, PhD
CONTACTJonalyn Edades, RN
PRINCIPAL_INVESTIGATORLaura Melado, PhD
ART Fertility Clinics LLC
Outcome results
None listed