Correlation Between Serum Uric Acid and Pulmonary Hypertension in Obstructive Sleep Apnea Syndrome

Correlation Between Serum Uric Acid and Pulmonary Arterial Hypertension Based on Echo Probability in Patients With Obstructive Sleep Apnea Syndrome

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05967754

Enrollment

100

Registered

2023-08-01

Start date

2018-01-01

Completion date

2020-12-01

Last updated

2023-08-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstructive Sleep Apnea

Brief summary

This study aimed to correlate serum uric acid levels and PAH in OSAHS patients.

Detailed description

Obstructive sleep apnea-hypopnea syndrome is the most common form of SRBDs. Recurrent hypoxia, that accompanies OSAHS increases the degradation of ATP, which in turn increase uric acid concentration that can be used as a biomarker of tissue hypoxia in OSAHS. There is still debate about whether OSAHS is an independent contributor to pulmonary arterial hypertension. AIM OF THE WORK This study aimed to correlate serum uric acid levels and PAH in OSAHS patients. Methods We enrolled 100 patients diagnosed with OSAHS using polysomnography. Patients were divided into three severity groups: mild OSA (5 ≤ AHI \< 15), moderate OSA (15 ≤ AHI \< 30), and severe (30 ≤ AHI \< 60). Serum uric acid was measured the morning after polysomnography. All patients underwent standard echocardiograms, and Pulmonary artery systolic pressure calculation was done.

Interventions

DIAGNOSTIC_TESTpolysomnography

polysomnography and serum uric acid measurement

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

SCREENING

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Clinical diagnosis of OSAHS by overnight polysomnography (AHI ≥ 5/ hr) * ≥18 years old.

Exclusion criteria

* Other sleep disorders as narcolepsy or hypersomnia were excluded as well as Patients with neuropsychiatric disorders. * Hemodynamically unstable patients * Patients with other chronic respiratory or cardiac diseases * Patients with other known causes of pulmonary hypertension * Patients with any disease or on medication that could alter excretion or urinary metabolism of uric acid such as Excessive uric acid production

Design outcomes

Primary

Measure	Time frame	Description
This study aimed to correlate serum uric acid levels and Pulmonary Arterial Hypertension in Obstructive Sleep Apnea Hypopnea Syndrome patients.	one Year	This study aimed to correlate serum uric acid levels and Pulmonary Arterial Hypertension in Obstructive Sleep Apnea Hypopnea Syndrome patients.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026