Localized Analysis of Normalized Distance From Scalp to Cortex and Personalized Evaluation (LANDSCAPE)

Localized Analysis of Normalized Distance From Scalp to Cortex and Personalized Evaluation (LANDSCAPE): A Project of MRI-informed Computational Head Model

Status

Enrolling by invitation

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05967390

Enrollment

488

Registered

2023-08-01

Start date

2023-06-15

Completion date

2025-06-14

Last updated

2025-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aging, Dementia Alzheimers, Dementia Frontotemporal, Depression in Old Age, Parkinson Disease

Keywords

Aging, Scalp-to-cortex distance, Transcranial brain stimulation, Parkinson disease, Simulation, Predictor

Brief summary

Scalp to cortex distance (SCD), as a key technological parameter of brain stimulation, has been highlighted in the guidelines of non-invasive brain stimulation. However, in the context of age-related brain changes, the region-specific SCD and its impact on stimulation-induced electric field in different types of neurodegenerative diseases remain unclear.

Detailed description

Objective: This study aimed to investigate the region-specific SCD and its relationship with morphometric features and cognitive function in age- and disease-specific populations. Methods: The SCD and cortical thickness (CT) of left primary motor cortex (M1) and dorsolateral prefrontal cortex (DLPFC) were measured in cognitively normal adults and dementia patients. CT-adjusted SCD was used to control the influence of CT on SCD. Head model was developed to simulate the impact of SCD on the electric field induced by transcranial electrical stimulation.

Interventions

DEVICETranscranial Magnetic Stimulation

One time for each day, lasting for three weeks.

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

60 Years to 95 Years

Healthy volunteers

Yes

Inclusion criteria

* Right-handed as assessed by the Edinburgh Inventory * Able to attend TMS interventions * Consent * Independent in daily life activities

Exclusion criteria

* Uncorrected visual or auditive deficits not allowing the realization of the test * Evolutive disease (such as cancer) * Neurological or psychiatric antecedent * Counter-indication to MRI

Design outcomes

Primary

Measure	Time frame	Description
Scalp-to-cortex distance will be measured using geometric brain model	Baseline	Scalp-to-cortex distance (SCD), as a geometric feature, will measured in the Brainsight TMS neuronavigation system.

Countries

Hong Kong

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 4, 2026