Transplant-Related Disorder, Urinary Tract Infections
Conditions
Brief summary
Urinary tract infections (UTIs) with extended-spectrum -lactamase (ESBL)-positive Enterobacteriums (ESBL-E) are a common infectious complication of renal transplant recipients, with 10% of patients suffering from UTIs with ESBL-E within the first year posttransplant. Moreover, recurrence rates of UTI caused by ESBL-E are almost three times higher than those by cephalosporin-susceptible Enterobacteriums demonstrating the decreased efficacy of antibiotics in the treatment of these UTIs.
Detailed description
According to each patient's urine culture, resistant urinary tract infections will be treated with specific phages and patients will be followed up with their urine cultures for response to therapy.
Interventions
BIOLOGICALPhage
Inserting specific specimen of phages in to the bladder
Sponsors
Shahid Beheshti University of Medical Sciences
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Stable Kidney Transplant Recipients * Stable Immunosupression Dose * Stable Renal Function * Resistant Urinary Infection with Positive UC
Exclusion criteria
* Rejection periods * Frail Patients
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Urine culture | 1 week after administration | Negative Urine Culture |
Countries
Iran
Outcome results
None listed